为了识别正在接受初始化疗的肺癌患者的症状群（SC），并识别每个SC的前哨症状。采用方便抽样方法招募正在接受初始化疗的肺癌患者。使用一般人口统计问卷、MD 安德森症状清单（包括肺癌模块）和记录症状最初发生的时间表来收集患者信息。采用Walktrap算法识别SC，并结合Apriori算法结合症状初始出现时间识别每个SC内的前哨症状。共有169名肺癌患者参与本研究，识别出4个SC：心理 SC（记忆困难、悲伤、口干、麻木或刺痛以及痛苦）、躯体 SC（疼痛、疲劳、睡眠障碍和嗜睡）、呼吸 SC（咳嗽、咳痰、胸闷和气短），和消化 SC（恶心、食欲不振、便秘、呕吐和体重减轻）。悲伤、疲劳和咳嗽分别被确定为心理、躯体和呼吸 SC 的前哨症状。然而，没有发现消化性 SC 的前哨症状。接受化疗的肺癌患者会遇到一系列症状，通常表现为 SC。每个 SC 的哨兵症状都比其他症状出现得更早，并以其敏感性、重要性和驱动力为特征。它是SC的重要指标，并承担着哨兵的角色。针对哨兵症状可能是一种很有前景的策略，可用于确定最佳干预时机以及减轻或减缓 SC 内其他症状的进展。© 2024。作者。

To identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to identify the sentinel symptoms of each SC.A convenience sampling method was used to recruit patients with lung cancer who were undergoing their initial chemotherapy treatment. Patient information was collected using the General Demographic Questionnaire, MD Anderson Symptom Inventory (including the lung cancer module) and a schedule documenting the initial occurrence of symptoms. The Walktrap algorithm was employed to identify SCs, while sentinel symptoms within each SC were identified using the Apriori algorithm in conjunction with the initial occurrence time of symptoms.A total of 169 patients with lung cancer participated in this study, and four SCs were identified: the psychological SC (difficulty remembering, sadness, dry mouth, numbness or tingling, and distress), somatic SC (pain, fatigue, sleep disturbance, and drowsiness), respiratory SC (coughing, expectoration, chest tightness, and shortness of breath), and digestive SC (nausea, poor appetite, constipation, vomiting, and weight loss). Sadness, fatigue, and coughing were identified as sentinel symptoms of the psychological, somatic, and respiratory SCs, respectively. However, no sentinel symptom was identified for the digestive SC.Patients with lung cancer who are undergoing chemotherapy encounter a spectrum of symptoms, often presenting as SCs. The sentinel symptom of each SC emerges earlier than the other symptoms and is characterized by its sensitivity, significance, and driving force. It serves as a vital indicator of the SC and assumes a sentry role. Targeting sentinel symptoms might be a promising strategy for determining the optimal timing of interventions and for mitigating or decelerating the progression of the other symptoms within the SC.© 2024. The Author(s).