恶性肿瘤对人类的生活质量构成严重威胁。我国恶性肿瘤的患病率呈稳步上升趋势。目前，临床干预包括手术、放射治疗和药物治疗的单独或组合。然而，这些方法无法完全根除恶性肿瘤细胞，常常导致转移和复发。相反，肿瘤生物疗法因其安全性、有效性和最小的副作用而成为预防和治疗恶性肿瘤的第四种令人鼓舞的方法。目前，采用了一系列肿瘤生物治疗技术，包括基因治疗、肿瘤疫苗、单克隆抗体治疗、癌症干细胞治疗、细胞因子治疗和过继性细胞免疫治疗。本研究旨在全面回顾恶性肿瘤生物治疗的最新进展。© 2024。作者。

Malignant tumors pose a grave threat to the quality of human life. The prevalence of malignant tumors in China is steadily rising. Presently, clinical interventions encompass surgery, radiotherapy, and pharmaceutical therapy in isolation or combination. Nonetheless, these modalities fail to completely eradicate malignant tumor cells, frequently leading to metastasis and recurrence. Conversely, tumor biotherapy has emerged as an encouraging fourth approach in preventing and managing malignant tumors owing to its safety, efficacy, and minimal adverse effects. Currently, a range of tumor biotherapy techniques are employed, including gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy. This study aims to comprehensively review the latest developments in biological treatments for malignant tumors.© 2024. The Author(s).