子宫内膜癌（EC）是西方国家女性最常见的恶性肿瘤之一。这项研究旨在评估德国二十年来患者治疗的数据，以评估手术、放疗和化疗的发展和效果。这项回顾性登记研究包括 2000 年至 2020 年间诊断的 34,349 名 EC 患者。患者被分为五个风险组。通过Kaplan-Meier法以及单变量和多变量Cox回归分析总体生存率，以评估危险因素和治疗方案。在研究期间，与开放手术相比，微创手术的使用更频繁，并且与更好的总体生存率相关。晚期 EC 患者更有可能接受多模式治疗。中危EC患者手术后预后良好，加用放疗后预后进一步改善。高危患者的预后较差，但明显受益于额外的放射治疗。当手术和放疗中加入化疗时，具有非子宫内膜样组织学的老年高危患者的生存率得到改善。我们的研究包括对德国临床癌症登记处二十年来子宫内膜癌护理数据的大量分析。我们观察到微创手术有所增加。有证据表明，微创手术并不逊色于开放手术。根据风险组和年龄，辅助放疗和化疗可进一步提高生存率。© 2024。作者。

Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, and chemotherapy.This retrospective registry study included 34,349 EC patients diagnosed between 2000 and 2020. Patients were classified into five risk groups. Overall survival was analyzed by Kaplan-Meier method as well as univariable and multivariable Cox regression to evaluate risk factors and treatment options.Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy. Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy.Our study includes a large analysis of data from German clinical cancer registries on the care of endometrial cancer during two decades. We observed an increase of minimal invasive surgery. There is evidence that minimal invasive surgery is not inferior to open surgery. Adjuvant radio- and chemotherapy further improves survival depending on risk group and age.© 2024. The Author(s).