尚无研究关注 LE8 与癌症风险和死亡的关联。我们的目的是检查 LE8 与死亡和癌症的关联。共有 94733 名年龄为 51.42±12.46 岁的成年人和 77551 名年龄为 54.09±12.06 岁的参与者分别纳入纵向和轨迹分析。基线 LE8 根据美国心脏协会标准分为三组，并根据潜在混合模型分为三种轨迹模式。我们审查了医疗记录和临床检查，以确认 2006 年至 2020 年期间发生的癌症。死亡信息是从省级生命统计办公室收集的。使用 Cox 模型。在 14 年的随访期间记录了 12807 例全因死亡和 5060 例癌症。相对于基线时 LE8 较高的参与者，LE8 水平较低的参与者的死亡率和癌症发生风险显着增加。所有这些风险均随着 LE8 级别的降低而呈增加趋势。与此同时，轨迹分析在大约 10 年后记录了 7483 例全因死亡和 3037 例癌症事件。 LE8 与死亡和癌症的关联与纵向研究相同。在癌症亚型分析中，LE8 对结直肠癌风险有很强的影响。此外，LE8 与死亡之间的关联的切点为 56.67，而 LE8 与癌症发生之间的关联的切点变为 64.79。这些关联在年轻人中得到增强。LE8 与死亡和癌症风险存在显着关联，尤其是对于年轻人而言。© 2024。作者。

No study has concentrated on the association of LE8 with cancer risk and death. We aim to examine the association of LE8 with death and cancer.A total of 94733 adults aged 51.42 ± 12.46 years and 77551 participants aged 54.09±12.06 years were enrolled in longitudinal and trajectory analysis respectively. Baseline LE8 was divided into three groups based on the American Heart Association criteria and three trajectory patterns by latent mixture models. We reviewed medical records and clinical examinations to confirm incident cancer during the period from 2006 to 2020. Death information was collected from provincial vital statistics offices. Cox models were used.12807 all-cause deaths and 5060 cancers were documented during a 14-year follow-up. Relative to participants with high LE8 at baseline, participants with lower levels of LE8 have a significantly increased risk of mortality and incident cancer. All these risks have an increasing trend with LE8 level decreasing. Meanwhile, the trajectory analysis recorded 7483 all-cause deaths and 3037 incident cancers after approximately 10 years. The associations of LE8 with death and cancer were identical to the longitudinal study. In the subtype cancer analysis, LE8 has a strong effect on colorectal cancer risk. Moreover, the cut point is 56.67 in the association between LE8 and death, while the cut point altered to 64.79 in the association between LE8 and incident cancers. These associations were enhanced among younger adults.There was a significant association of LE8 with death and cancer risk, especially for the young population.© 2024. The Author(s).