可编程设计的随机 RNA 纳米行走器，用于超灵敏 miRNA 检测。
Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection.
发表日期：2024 May 28
作者：
Dan Zhu, Dongxia Zhao, Yang Hu, Tianhui Wei, Tong Su, Shao Su, Jie Chao, Lianhui Wang
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
开发了一种由双链体特异性核酸酶 (DSN) 驱动的可编程随机 RNA 纳米行走器。通过利用基于聚腺嘌呤的球形核酸 (polyA-SNA) 精确调节 DNA 轨迹的密度，nanowalker 展示了其以快速动力学和阿托摩尔灵敏度识别 miRNA-21、miRNA-486 和 miRNA-155 的能力，将其定位为癌症临床监测的一个有前途的选择。
A programmably engineered stochastic RNA nanowalker powered by duplex-specific nuclease (DSN) is developed. By utilizing poly-adenine-based spherical nucleic acids (polyA-SNA) to accurately regulate the densities of DNA tracks, the nanowalker showcases its capability to identify miRNA-21, miRNA-486, and miRNA-155 with quick kinetics and attomolar sensitivity, positioning it as a promising option for cancer clinical surveillance.