本研究的目的是评估成人高血压患者的综合膳食抗氧化指数 (CDAI) 与全因死亡率和特定原因死亡率之间的相关性。队列研究由来自 NHANES 数据库的成年高血压参与者组成，涵盖 9 个周期2001年至2018年，随访至2019年12月31日。利用多变量Cox回归分析确定风险比（HR）及其相应的95%置信区间，评估CDAI与全因风险之间的关系和特定原因死亡率。为了进一步研究 CDAI 与成人高血压死亡率之间的关联，我们采用了 Kaplan-Meier 生存曲线、限制三次样条 (RCS)、亚组分析和敏感性分析。该分析包括 16,713 名成人高血压患者（平均年龄 56.93±0.23 岁） ，8,327 [49.61%] 男性）。在平均随访时间102.11±1.22个月内，发生了3,908例（18.08%）全因死亡、1,082例（4.84%）心血管死亡和833例（3.80%）癌症死亡。与 CDAI 最低四分位数相比，最高四分位数参与者的全因死亡率加权多变量风险比为 0.77（95% CI，0.68-0.87），心血管死亡率为 0.83（95% CI，0.67-1.04），癌症死亡率为 0.64（95% CI，0.50-0.82）。 RCS 分析表明 CDAI 与全因死亡率和癌症死亡率呈非线性关联，CDAI 与心血管死亡率呈线性关联。亚组分析和敏感性分析的结果是稳健的。较高的 CDAI 与成人高血压患者全因死亡率、心血管死亡率和癌症死亡率的降低相关。我们的研究结果强调了抗氧化饮食对于改善成人高血压患者预后的重要性。版权所有 © 2024 Qing、Shen 和 Xu。

The objective of this study is to assess the correlation between composite dietary antioxidant index (CDAI) with all-cause mortality and cause-specific mortality in adults with hypertension.The cohort study comprised adult participants with hypertension from the NHANES database, spanning 9 cycles from 2001 to 2018. Follow-up was conducted until December 31, 2019. Multi-variable Cox regression analysis was utilized to ascertain hazard ratios (HR) and their corresponding 95% confidence intervals, evaluating the relationship between CDAI and the risks of all-cause and cause-specific mortality. To further investigate the association between CDAI and mortality rates in adults with hypertension, Kaplan-Meier survival curves, restricted cubic splines (RCS), subgroup analyses and sensitivity analyses were employed.The analysis included 16,713 adults with hypertension (mean age 56.93 ± 0.23 years, 8,327 [49.61%] male). During the mean follow-up time 102.11 ± 1.22 months, with 3,908 (18.08%) all-cause mortality occurred, 1,082 (4.84%) cardiovascular mortality and 833 (3.80%) cancer mortality. Compared to the lowest quartile of CDAI, the weighted multivariate hazard ratios of participants in the highest quartile was 0.77 (95% CI, 0.68-0.87) for all-cause mortality, 0.83 (95% CI, 0.67-1.04) for cardiovascular mortality, and 0.64 (95% CI, 0.50-0.82) for cancer mortality. RCS analysis demonstrated a nonlinear association of CDAI with all-cause and cancer mortality, and a linear association between CDAI and cardiovascular mortality. The results were robust in subgroup analyses and sensitivity analyses.Higher CDAI is associated with reduced all-cause mortality, cardiovascular mortality, and cancer mortality in hypertensive adults. Our findings highlight the importance of an antioxidant diet in improving outcomes in adults with hypertension.Copyright © 2024 Qin, Shen and Xu.