自身免疫性疾病 (AID) 与口咽癌 (OPC) 相关，但这种关联的确切性质仍不清楚。本研究旨在探讨艾滋病对发生 OPC 风险的潜在因果影响。有关艾滋病的信息是从英国生物银行数据集和 Finn Gen 研究中收集的。 OPC 数据来源于 IEU Open GWAS 项目。所有数据均来自欧洲人群。逆方差加权 (IVW) 到两样本孟德尔随机化 (MR) 并辅以加权中位数和 MR Egger 验证分析。哮喘 (AS)、多发性硬化症 (MS) 和类风湿性关节炎 (RA) 的发展影响了以下风险：开发OPC。然而，反向 MR 分析并未提供 OPC 对艾滋病影响的证据。使用 MR 进行的敏感性分析证实了 IVW 结果。 IVW 结果表明，AS 的 OR 值为 1.004，MS 的 OR 值为 0.936，RA 的 OR 值为 1.0002。这项 MR 研究支持欧洲人群中 OPC 哮喘与类风湿性关节炎之间的因果关系。多发性硬化症可预防 OPC。版权所有© 2024 Dennis Barber Ltd.

Autoimmune diseases (AIDs) are linked to oropharyngeal cancer (OPC), but the exact nature of this association remains unclear. This study aims to examine the potential causal effect of AIDs on the risk of developing OPC.Information regarding AIDs was collected from the UK Biobank dataset and the Finn Gen study. OPC data were sourced from the IEU Open GWAS project. All data were derived from European populations. Inverse variance weighted (IVW) to two-sample Mendelian randomization (MR) was complemented by weighted median and MR Egger validation analyses.The development of asthma (AS), multiple sclerosis (MS), and rheumatoid arthritis (RA) influenced the risk of developing OPC. However, the reverse MR analysis did not provide evidence for the impact of OPC on AIDs. Sensitivity analysis using MR corroborated the IVW results. The IVW results indicate OR values of 1.004 for AS, 0.936 for MS, and 1.0002 for RA.This MR study supports a causal relationship between asthma and rheumatoid arthritis for OPC in a European population. Multiple sclerosis was protective against OPC.Copyright© 2024 Dennis Barber Ltd.