生活在沿海地区的脂溢性角化病患者血清骨化二醇、阳光指数和维生素 D 摄入量之间的相关性。
Correlation Among Serum Calcidiol, Sun Index, and Vitamin D Intake in Individuals With Seborrheic Keratoses Living in Coastal Area.
发表日期:2024 Apr 01
作者:
Izzah Aulia, Larisa Paramitha Wibawa, Lis Surachmiati Suseno, Nurul Ratna Mutu Manikam
来源:
Food & Function
摘要:
脂溢性角化病 (SK) 是良性表皮肿瘤,高阳光照射是主要危险因素。维生素 D 缺乏也被认为在其发病机制中发挥了一定作用。目前还没有关于印度尼西亚沿海地区居民的 SK、骨化二醇水平、维生素 D 摄入量和阳光指数 (SI) 的数据。评估 1) 血清骨化二醇水平与 SI 和维生素 D 摄入量以及 2) 病变之间的相关性居住在沿海地区的 SK 患者的大小与 SI 和血清骨化二醇水平的关系。这是一项横断面研究。我们使用阳光指数问卷和维生素 D 半定量食物频率问卷进行访谈;身体检查;皮肤镜检查以确定最大 SK 病变大小;以及居住在雅加达北部 Cilincing 区的 SK 参与者血清骨化二醇水平的测量。采用 Spearman 相关性检验评估变量之间的关系。对 39 名年龄在 19-59 岁的 SK 参与者进行了分析。 SK最大直径、SI、血清骨化二醇和维生素 D 摄入量的中位数分别为 2 (1-10) mm、3.95 (1.1-23.52)、14.3 (5.25-35.30) ng/ml 和 4.3 (0.1-30.1) ng/ml分别为微克/天。 SI和维生素D摄入量与骨化二醇水平没有显着相关性。同样,SI 和骨化二醇水平与最大 SK 病变大小没有显着相关。我们发现该沿海人群的骨化二醇水平和维生素 D 摄入量较低。 SI和维生素D的摄入量与骨化二醇水平没有相关性。此外,骨化二醇水平和SI与病变最大直径没有相关性。
Seborrheic keratoses (SK) are benign epidermal tumors with high sun exposure as a major risk factor. Vitamin D deficiency is also thought to play a role in its pathogenesis. There has been no data regarding SK, calcidiol level, vitamin D intake, and sun index (SI) among people living in coastal areas in Indonesia.To assess the correlation between 1) serum calcidiol levels with SI and vitamin D intake and 2) lesion size with SI and serum calcidiol level among SK patients living in a coastal area.This is a cross-sectional study. We performed interviews using the sun index questionnaire and semiquantitative food frequency questionnaire for vitamin D; physical examination; dermoscopy to determine the largest SK lesion size; and measurement of serum calcidiol levels in participants with SK living in Cilincing District, North Jakarta. Spearman correlation test was used to assess the relationship between variables.Thirty-nine participants with SK aged 19-59 years were analyzed. The median of the SK largest diameter, SI, serum calcidiol, and vitamin D intake was 2 (1-10) mm, 3.95 (1.1-23.52), 14.3 (5.25-35.30) ng/ml, and 4.3 (0.1-30.1) mcg/day, respectively. SI and vitamin D intake were not significantly correlated with calcidiol levels. Similarly, SI and calcidiol levels were not significantly correlated with the largest SK lesion size.We found low calcidiol levels and vitamin D intake in this coastal population. The SI and vitamin D intake had no correlations with calcidiol levels. Furthermore, calcidiol levels and SI had no correlations with the lesion largest diameter.