随着纳米技术和创新材料的进步，氧化石墨烯纳米粒子（GONP）由于其独特的物理化学特性而在各种类型的纳米材料中引起了广泛的关注。然而，科学和工业层面的使用也引起了人们对其与生物系统的毒理学相互作用的关注。了解这些相互作用对于制定 GONP 在生物医学和环境技术等各个领域的应用指南和建议至关重要。这篇综述对多种细胞系（包括人全血培养物、树突状细胞、巨噬细胞和多种癌细胞系）与 GONP 免疫毒性相关的生物过程提供了重要的见解和深入分析。这项工作强调了氧化石墨烯纳米颗粒与免疫系统之间复杂的相互作用，揭示了一系列免疫毒性后果，如炎症、免疫抑制、免疫刺激、超敏反应、自身免疫和细胞功能障碍。此外，在小鼠和斑马鱼等体内模型中也突出了免疫毒性作用，深入了解了 GO 纳米颗粒的细胞毒性。该研究为研究人员、政策制定者和实业家了解和利用 GONP 通过控制措施对人类健康和环境的有益应用提供了宝贵的回顾。版权所有 © 2024 作者。由 Elsevier Masson SAS 出版。保留所有权利。

With advancements in nanotechnology and innovative materials, Graphene Oxide nanoparticles (GONP) have attracted lots of attention among the diverse types of nanomaterials owing to their distinctive physicochemical characteristics. However, the usage at scientific and industrial level has also raised concern to their toxicological interaction with biological system. Understanding these interactions is crucial for developing guidelines and recommendations for applications of GONP in various sectors, like biomedicine and environmental technologies. This review offers crucial insights and an in-depth analysis to the biological processes associated with GONP immunotoxicity with multiple cell lines including human whole blood cultures, dendritic cells, macrophages, and multiple cancer cell lines. The complicated interactions between graphene oxide nanoparticles and the immune system, are highlighted in this work, which reveals a range of immunotoxic consequences like inflammation, immunosuppression, immunostimulation, hypersensitivity, autoimmunity, and cellular malfunction. Moreover, the immunotoxic effects are also highlighted with respect to in vivo models like mice and zebrafish, insighting GO Nanoparticles' cytotoxicity. The study provides invaluable review for researchers, policymakers, and industrialist to understand and exploit the beneficial applications of GONP with a controlled measure to human health and the environment.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.