胰腺神经内分泌肿瘤的手术治疗和长期评估。
Surgical Management and Long-Term Evaluation of Pancreatic Neuroendocrine Tumors.
发表日期：2024 Aug
作者：
Shadin Ghabra, Bhavishya Ramamoorthy, Stephen G Andrews, Samira M Sadowski
来源：
Cellular & Molecular Immunology
摘要：
胰腺神经内分泌肿瘤（PNET）起源于神经内分泌细胞，是一类罕见的异质性肿瘤，且发病率不断增加。 PNET 的诊断、分期、治疗和预后在很大程度上取决于组织学特征和生物学机制的确定。在此，作者概述了 PNET 的诊断检查（生物标志物和成像）、分级和分期。作者还探索了相关的基因突变和分子途径，并描述了手术和全身治疗方式的最新指南。由爱思唯尔公司出版。
Pancreatic neuroendocrine tumors (PNETs) arise from neuroendocrine cells and are a rare class of heterogenous tumors with increasing incidence. The diagnosis, staging, treatment, and prognosis of PNETs depend heavily on identifying the histologic features and biological mechanisms. Here, the authors provide an overview of the diagnostic workup (biomarkers and imaging), grade, and staging of PNETs. The authors also explore associated genetic mutations and molecular pathways and describe updated guidelines on surgical and systemic treatment modalities.Published by Elsevier Inc.