二硫化物是一个重要的化合物家族，具有多种生物活性，可以影响生理和病理状态之间的动态平衡。最近发表的一项研究发现，二硫键的异常积累对细胞具有致命作用。这种细胞死亡机制被称为二硫下垂，不同于其他已知的细胞死亡机制，包括铜凋亡、细胞凋亡、坏死性凋亡和细胞焦亡。二硫化物下垂与癌症（特别是子宫内膜癌）发展之间的关系仍不清楚。为了解决这一知识差距，我们对癌症基因组图谱数据库中的样本进行了初步分析。将样本平均分为训练组和测试组。共提取2308个差异表达基因，其中11个用于构建预后模型。根据预后模型计算的风险评分，将样本分为高风险组和低风险组。两组之间的生存时间、肿瘤突变负荷和微卫星不稳定性评分存在显着差异。此外，还预测了治疗效果的组间差异。与文献中其他模型的比较表明，该预后模型具有更好的预测能力。本研究结果为理解二硫下垂与子宫内膜癌的关系提供了一个总体框架，可用于临床评估和选择合适的个性化治疗策略。 © 2024 作者。约翰·威利 (John Wiley) 出版的《癌症创新》

Disulfide, an essential compounds family, has diverse biological activity and can affect the dynamic balance between physiological and pathological states. A recently published study found that aberrant accumulation of disulfide had a lethal effect on cells. This mechanism of cell death, named disulfidptosis, differs from other known cell death mechanisms, including cuproptosis, apoptosis, necroptosis, and pyroptosis. The relationship between disulfidptosis and development of cancer, in particular endometrial carcinoma, remains unclear.To address this knowledge gap, we performed a preliminary analysis of samples from The Cancer Genome Atlas database. The samples were divided equally into a training group and a test group. A total of 2308 differentially expressed genes were extracted, and 11 were used to construct a prognostic model.Based on the risk score calculated using the prognostic model, the samples were divided into a high-risk group and a low-risk group. Survival time, tumor mutation burden, and microsatellite instability scores differed significantly between the two groups. Furthermore, a between-group difference in treatment effect was predicted. Comparison with other models in the literature indicated that this prognostic model had better predictive anility.The results of this study provide a general framework for understanding the relationship between disulfidptosis and endometrial cancer that could be used for clinical evaluation and selection of appropriate personalized treatment strategies.© 2024 The Authors. Cancer Innovation published by John Wiley & Sons Ltd on behalf of Tsinghua University Press.