非小细胞肺癌（NSCLC）预后较差。经血管介入治疗是治疗NSCLC的重要方法。药物洗脱珠支气管动脉化疗栓塞（DEB-BACE）是一种利用装载化疗药物的DEB进行BACE的技术。本研究旨在进行荟萃分析，全面评估 DEB-BACE 治疗 NSCLC 的有效性和安全性，并探讨 NSCLC 的新治疗策略。万方、中国国家知识基础设施、Medline（来自 PubMed）、Cochrane Library、Scopus 和将于2024年11月检索Embase数据库。将进行荟萃分析以评估DEB-BACE治疗NSCLC的有效性和安全性。将应用以下关键字：“癌，非小细胞肺癌”，“非小细胞肺癌”，“药物洗脱珠支气管动脉化疗栓塞”和“药物洗脱珠”。将包括比较 DEB-BACE 与其他 NSCLC 治疗方案疗效的中文或英文报告。病例报告、单臂研究、会议论文、无全文摘要以及以中英文以外语言发表的报告将不予考虑。 《干预系统评价 Cochrane 手册》将用于独立评估每项纳入研究的偏倚风险。如果研究之间存在显着异质性，将通过亚组和敏感性分析探讨异质性的可能来源。对于数据的统计分析，将使用 RevMan V.5.3。该荟萃分析将在完成后寻求在同行评审期刊上发表。本研究不需要伦理批准，因为它是一项基于数据库的研究。CRD42023411392.© 作者（或其雇主）2024。根据 CC BY-NC 允许重复使用。禁止商业再利用。请参阅权利和权限。由英国医学杂志出版。

Non-small cell lung cancer (NSCLC) has a poor prognosis. Transvascular intervention is an important approach for treating NSCLC. Drug-eluting bead bronchial artery chemoembolisation (DEB-BACE) is a technique of using DEBs loaded with chemotherapeutic drugs for BACE. This study aims to conduct a meta-analysis to comprehensively assess the effectiveness and safety of DEB-BACE in treating NSCLC and investigate a novel therapeutic strategy for NSCLC.Wanfang, China National Knowledge Infrastructure, Medline (via PubMed), Cochrane Library, Scopus and Embase databases will be searched in November 2024. A meta-analysis will be conducted to assess the effectiveness and safety of DEB-BACE in the treatment of NSCLC. The following keywords will be applied: "Carcinoma, Non-Small-Cell Lung", "Non-Small Cell Lung Cancer", "Drug-Eluting Bead Bronchial Arterial Chemoembolization" and "drug-eluting beads". Reports in Chinese or English comparing the efficacy of DEB-BACE with other NSCLC treatment options will be included. Case reports, single-arm studies, conference papers, abstracts without full text and reports published in languages other than English and Chinese will not be considered. The Cochrane Handbook for Systematic Reviews of Interventions will be used to independently assess the risk of bias for each included study. In case of significant heterogeneity between studies, possible sources of heterogeneity will be explored through subgroup and sensitivity analysis. For the statistical analysis of the data, RevMan V.5.3 will be used.This meta-analysis will seek publication in a peer-reviewed journal on completion. Ethical approval is not required for this study as it is a database-based study.CRD42023411392.© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.