【第507例：溶血性贫血、细小病毒B19、多器官功能障碍】。
[The 507th case: hemolytic anemia, parvovirus B19, and multiple organ dysfunction].
发表日期：2024 Jul 01
作者：
Y Liu, X H Zhang, L Q Cao, X J Huang, X D Mo
来源：
Stem Cell Research & Therapy
摘要：
一名患有高危急性B细胞淋巴细胞白血病的19岁男性患者接受了半相合干细胞移植。反复出现贫血，血浆细小病毒B19核酸阳性。该患者被诊断患有冷凝集素综合征和多器官功能障碍，包括呼吸衰竭和肝炎。在病毒感染与冷凝集素综合征治疗的冲突中，我们提供了支持治疗、补体抑制剂控制溶血以及抗病毒治疗。经过及时的糖皮质激素和免疫抑制剂治疗，患者取得了良好的反应。
A 19-year-old male patient with high-risk acute B-cell lymphoblastic leukemia received haploidentical stem cell transplantation. He developed anemia repeatedly and parvovirus B19 nucleic acid was positive in blood plasma. The patient was diagnosed with cold agglutinin syndrome and multiple organ dysfunction including respiratory failure and hepatitis. In the conflict between viral infection and the treatment of cold agglutinin syndrome, we provided supportive treatment, complement inhibitors to control hemolysis, and antiviral therapy. After timely glucocorticoid and immunosuppressant therapy, the patient had achieved a good response.