口腔鳞状细胞癌（OSCC）的发病率逐年上升，成为全球主要的健康问题。但OSCC的分子发病机制目前尚不清楚。为了研究OSCC的潜在发病机制，筛选了差异表达基因（DEG），并使用多个数据库进行肿瘤分期、表达、预后、蛋白质-蛋白质相互作用（PPI）网络、模块和功能富集分析。此外，我们还确定了SP110作为关键候选基因，并使用多个数据库对其进行了各种分析。研究表明共有211个常见的DEG，并且它们在各种GO术语和通路中得到丰富。同时，1个DEG与短无病生存期显着相关，4个DEG与总生存期相关，12个DEG与肿瘤分期密切相关。此外，SP110 与口腔癌患者的甲基化水平、HPV 状态、肿瘤分期、性别、种族、肿瘤分级、年龄和总体/无病生存率以及免疫过程显着相关。 SP110的拷贝数变异显着影响免疫浸润的丰度。因此，我们推测 SP110 可用作 OSCC 的诊断和治疗生物标志物，并有助于进一步了解口腔癌发生。© 2024。作者获得 Springer Science Business Media, LLC（Springer 旗下公司）的独家许可自然。

The morbidity of oral squamous cell carcinoma (OSCC) has been rising year after year, making it a major global health issue. But the molecular pathogenesis of OSCC is currently unclear. To study the potential pathogenesis of OSCC, the differentially expressed genes (DEGs) were screened, and multiple databases were used to perform the tumor stage, expression, prognosis, protein-protein interaction (PPI) networks, modules, and the functional enrichment analysis. Moreover, we have identified SP110 as the key candidate gene and conducted various analyses on it using multiple databases. The research indicated that there were 211 common DEGs, and they were enriched in various GO terms and pathways. Meanwhile, one DEG is significantly related to short disease-free survival, four are associated with overall survival, and 12 DEGs have close ties with tumor staging. Additionally, the SP110 is significantly associated with methylation level, HPV status, tumor staging, gender, race, tumor grade, age, and overall/disease-free survival of oral cancer patients, as well as the immune process. The copy number variation of SP110 significantly affected the abundance of immune infiltration. Therefore, we speculate that SP110 could be used as the diagnostic and therapeutic biomarker for OSCC, and can help to further understand oral carcinogenesis.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.