设计 CARD11-PIK3R3 T 细胞疗法作为癌症大规模杀伤性武器。
Engineered CARD11-PIK3R3 T-cell therapies as weapons of cancer mass destruction.
发表日期：2024 Jul
作者：
Wanlu Zhang, Min Wu, Yongye Huang
来源：
Cell Death & Disease
摘要：
加西亚等人。通过设计治疗性 T 细胞中自然发生的突变来显着提高抗肿瘤活性，发现了一种新的免疫治疗方法。作者确定了一种基因融合体 CARD11-PIK3R3，可在体外和体内增加激活蛋白 1 和核因子-κB 信号传导、白细胞介素 2 的产生以及肿瘤死亡。© 2024 作者。四川国际医学交流中心出版的MedComm
Garcia et al. discover a novel immunotherapy approach by engineering naturally occurring mutations in therapeutic T cells to strongly elevate anti-tumor activity. The authors identify a gene fusion, CARD11-PIK3R3, to increase activator protein 1 and nuclear factor-κB signaling, interleukin-2 production, and tumor death in vitro and in vivo .© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.