近年来，巨噬细胞在肺纤维化（PF）的症状和结构进展中的作用引起了学术界的广泛关注。本研究采用文献计量学方法探讨巨噬细胞与PF之间相关性的研究现状和重点领域，旨在全面了解它们的关系。本研究采用VOSviewer、CiteSpace和Microsoft Excel软件进行可视化和分析国家、机构、作者、期刊、共被引文献、关键词、相关基因、疾病等各个方面。这些分析是使用 Web of Science 核心合集数据库进行的。获得了 1990 年至 2023 年期间有关巨噬细胞和 PF 的 3,479 条记录的综合集合。多年来，关于这一主题的研究文献不断增加。值得注意的是，美国和中国在这一领域展现了最高水平的合作。通过仔细分析，在该特定领域内具有重大影响力的机构、作者和著名期刊已被确定为具有最高的出版物产出。相关研究主要集中在生物学和医学领域。流行的关键词包括肺纤维化、急性肺损伤、特发性肺纤维化等。值得注意的是，TGFβ1、TNF 和 CXCL8 成为最常研究的靶标，主要与细胞因子-细胞因子受体相互作用等信号通路相关。此外，相关疾病的聚类分析揭示了它们与癌症等疾病的相互关联。本研究采用文献计量方法来调查巨噬细胞和PF研究领域的知识结构和发展趋势。研究结果揭示了巨噬细胞和PF的介绍和研究热点，有助于更全面地了解巨噬细胞和PF。版权所有©2024 Min、Wu、Xu、Han、Yin、Pan、Sun、Zhang、Wan和Zhou。

The role of macrophages in the symptomatic and structural progression of pulmonary fibrosis (PF) has garnered significant scholarly attention in recent years. This study employs a bibliometric approach to examine the present research status and areas of focus regarding the correlation between macrophages and PF, aiming to provide a comprehensive understanding of their relationship.The present study employed VOSviewer, CiteSpace, and Microsoft Excel software to visualize and analyze various aspects such as countries, institutions, authors, journals, co-cited literature, keywords, related genes, and diseases. These analyses were conducted using the Web of Science core collection database.A comprehensive collection of 3,479 records pertaining to macrophages and PF from the period of 1990 to 2023 was obtained. Over the years, there has been a consistent increase in research literature on this topic. Notably, the United States and China exhibited the highest level of collaboration in this field. Through careful analysis, the institutions, authors, and prominent journals that hold significant influence within this particular field have been identified as having the highest publication output. The pertinent research primarily concentrates on the domains of Biology and Medicine. The prevailing keywords encompass pulmonary fibrosis, acute lung injury, idiopathic pulmonary fibrosis, and others. Notably, TGFβ1, TNF, and CXCL8 emerge as the most frequently studied targets, primarily associated with signaling pathways such as cytokine-cytokine receptor interaction. Additionally, cluster analysis of related diseases reveals their interconnectedness with ailments such as cancer.The present study employed bibliometric methods to investigate the knowledge structure and developmental trends in the realm of macrophage and PF research. The findings shed light on the introduction and research hotspots that facilitate a more comprehensive understanding of macrophages and PF.Copyright © 2024 Min, Wu, Xu, Han, Yin, Pan, Sun, Zhang, Wan and Zhou.