牛初乳补充剂作为抑郁症和药物滥用障碍治疗的新视角：一项随机安慰剂对照研究。
Bovine colostrum supplementation as a new perspective in depression and substance use disorder treatment: a randomized placebo-controlled study.
发表日期：2024
作者：
Krzysztof Durkalec-Michalski, Natalia Główka, Tomasz Podgórski, Weronika Odrobny, Marcin Krawczyński, Ryszard Botwina, Stanisław Bodzicz, Paulina M Nowaczyk
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
这项随机、安慰剂对照、双盲、平行研究旨在评估 3 个月补充牛初乳（BOV-COL；每天 8x400 毫克）对患有物质使用障碍的住院患者抑郁症治疗结果的影响（南苏丹）。假设 BOV-COL 补充剂作为附加治疗会导致选定的血液炎症标志物或神经递质发生有利的变化，从而与安慰剂 (PLA) 相比获得更好的抑郁症治疗结果。 明尼苏达州多相人格量表 2 评分≥的患者已录取60分。 29 名参与者（BOV-COL 组 n=18，PLA 组 n=11）完成了该方案。两组补充后贝克抑郁量表 II 平均评分均显着降低。然而，BOV-COL 组的汉密尔顿抑郁量表平均分 17 分有所下降，但 PLA 组则没有下降。在 BOV-COL 组中，白介素 (IL)-1、IL-6、IL-10、IL-6:IL-10 比率、IL-17 和肿瘤坏死因子 α (TNF-α) 降低），而在 PLA 组中只有 IL-6 下降。 BOV-COL 中白细胞亚群总数和差异的有利变化更为明显。神经递质浓度没有变化。BOV-COL 补充剂对于抑郁症和 SUD 患者来说是一种很有前景的附加疗法。版权所有 © 2024 Durkalec-Michalski、Główka、Podgórski、Odrobny、Krawczyński、Botwina、Bodzicz 和 Nowaczyk。
This randomized, placebo-controlled, double-blind, parallel study aimed to evaluate the effect of 3-month supplementation of bovine colostrum (BOV-COL; 8x400 mg per day) on the outcomes of depression treatment in hospitalized patients with substance use disorder (SUD). The hypothesis is that BOV-COL supplementation as an add-on treatment results in favorable alternations in selected blood inflammatory markers or neurotransmitters, leading to better depression treatment outcomes compared with placebo (PLA).Patients with a Minnesota Multiphasic Personality Inventory-2 score ≥60 points were enrolled. Twenty-nine participants (n=18 in the BOV-COL group and n=11 in the PLA group) completed the protocol.The mean Beck Depression Inventory-II score was significantly reduced after supplementation in both groups. However, the mean 17-point Hamilton Depression Rating Scale score was decreased in the BOV-COL group, but not in the PLA group. In the BOV-COL group, there was a reduction in interleukin (IL)-1, IL-6, IL-10, the IL-6:IL-10 ratio, IL-17, and tumor necrosis factor alpha (TNF-α), while in the PLA group only IL-6 decreased. Favorable alternations in the total count and differentials of white blood cell subsets were more pronounced in the BOV-COL. There were no changes in neurotransmitter concentrations.BOV-COL supplementation is a promising add-on therapy in patients with depression and SUD.Copyright © 2024 Durkalec-Michalski, Główka, Podgórski, Odrobny, Krawczyński, Botwina, Bodzicz and Nowaczyk.