尽管骨肉瘤的治疗取得了进展，但术后肿瘤复发、假体周围感染和严重骨缺损仍然是严重问题。据报道，硒纳米颗粒（SeNP）在MgFe-LDH纳米片（LDH）上的生长可开发出多功能纳米复合材料（LDH/Se），并在生物活性玻璃支架（BGS）上进一步修饰纳米复合材料以获得多功能平台。 BGS@LDH/Se) 用于术后骨肉瘤的综合管理。带负电荷的SeNPs在LDH表面的均匀分散抑制了毒性诱导的聚集和失活，从而增强了超氧化物歧化酶（SOD）的激活和超氧阴离子自由基（·O2 -）-H2O2的转化。同时，LDH纳米片中的Fe3可以通过消耗肿瘤微环境（TME）中的谷胱甘肽（GSH）而被还原为Fe2，从而可以催化H2O2生成剧毒的活性氧。更重要的是，掺入 SeNPs 显着促进了 BGS@LDH/Se 的抗菌和成骨特性。因此，所开发的BGS@LDH/Se平台可以同时抑制肿瘤复发和假体周围感染，并促进骨再生，从而为需要骨肉瘤切除和支架植入的患者提供术后“一站式”管理的巨大潜力。© 2024 作者。 《Advanced Science》由 Wiley‐VCH GmbH 出版。

Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain critical concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe-LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) and further modification of the nanocomposite on a bioactive glass scaffold (BGS) to obtain a versatile platform (BGS@LDH/Se) for comprehensive postoperative osteosarcoma management. The uniform dispersion of negatively charged SeNPs on the LDH surface restrains toxicity-inducing aggregation and inactivation, thus enhancing superoxide dismutase (SOD) activation and superoxide anion radical (·O2 -)-H2O2 conversion. Meanwhile, Fe3+ within the LDH nanosheets can be reduced to Fe2+ by depleting glutathione (GSH) in the tumor microenvironments (TME), which can catalyze H2O2 into highly toxic reactive oxygen species. More importantly, incorporating SeNPs significantly promotes the anti-bacterial and osteogenic properties of BGS@LDH/Se. Thus, the developed BGS@LDH/Se platform can simultaneously inhibit tumor recurrence and periprosthetic infection as well as promote bone regeneration, thus holding great potential for postoperative "one-stop-shop" management of patients who need osteosarcoma resection and scaffold implantation.© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.