利用传统疗法（TTS），例如化疗、基于活性氧的疗法和热疗法，诱导肿瘤细胞中的免疫原性细胞死亡（ICD）已成为激活抗肿瘤免疫反应的一种有前景的策略。然而，大多数TTS在诱导肿瘤ICD效应方面的有效性有限，阻碍了它们与免疫疗法联合应用。为了应对这一挑战，人们提出了各种智能策略来加强这些TTS的免疫激活作用，然后与免疫疗法实现协同抗肿瘤功效。这些策略主要侧重于增强肿瘤 ICD 效应或促进 TTS 期间抗原（由 ICD 肿瘤细胞释放）呈递过程，本综述对它们进行了系统总结。最后还讨论了TTS在肿瘤免疫调节应用中存在的瓶颈和前景。

The utilization of traditional therapies (TTS), such as chemotherapy, reactive oxygen species-based therapy, and thermotherapy, to induce immunogenic cell death (ICD) in tumor cells has emerged as a promising strategy for the activation of the antitumor immune response. However, the limited effectiveness of most TTS in inducing the ICD effect of tumors hinders their applications in combination with immunotherapy. To address this challenge, various intelligent strategies have been proposed to strengthen the immune activation effect of these TTS, and then achieve synergistic antitumor efficacy with immunotherapy. These strategies primarily focus on augmenting the tumor ICD effect or facilitating the antigen (released by the ICD tumor cells) presentation process during TTS, and they are systematically summarized in this review. Finally, the existing bottlenecks and prospects of TTS in the application of tumor immune regulation are also discussed.