揭露霍奇金淋巴瘤伪装成眼部炎症的不寻常表现:病例报告。
Unmasking an unusual presentation of Hodgkin's lymphoma masquerading as ocular inflammation: a case report.
发表日期:2024 Jul 04
作者:
Anna Zein-El-Din, Rami Abdo, Amina Elbachti, Gabriel Boustani, Dany Salik, Sayeh Pourjavan
来源:
MEDICINE & SCIENCE IN SPORTS & EXERCISE
摘要:
霍奇金淋巴瘤 (HL) 是一种极其罕见的眼部炎症病因,在葡萄膜炎和其他眼部疾病的典型检查中通常不考虑这种情况。先前报道了一些眼部炎症病例显示 HL,但就诊时没有 HL 的典型症状。认识到与 HL 相关的潜在眼部炎症可以促使眼科医生扩大诊断方法,并与内科部门合作研究这种罕见但重要的病因。一名 17 岁白人女性出现单侧全葡萄膜炎,后来被诊断为 HL。眼部检查结果为非坏死性巩膜炎、前葡萄膜炎、玻璃体炎、白色/黄色脉络膜视网膜病变、乳头炎和血管炎。左侧锁骨上淋巴结活检证实结节性硬化性霍奇金淋巴瘤 IIB 期的诊断。排除葡萄膜炎的其他原因。化疗使疾病得到缓解,眼部病变变得静止,并伴有持续性色素性脉络膜视网膜疤痕。在鉴别诊断偶尔可通过单侧眼部炎症发现的疾病时,应考虑霍奇金淋巴瘤。全面、多学科的方法是正确评估此类案例的关键。© 2024。作者。
Hodgkin's lymphoma (HL) is an extremely rare cause of ocular inflammation that is usually not considered in the typical workup of uveitis and other eye diseases. A few cases of ocular inflammation were reported previously showcasing HL with absence of typical symptoms of HL at presentation. Acknowledging the potential ocular inflammation associated with HL can prompt ophthalmologists to broaden their diagnostic approach and collaborate with internal medicine departments to investigate this rare yet significant etiology.A 17-year-old Caucasian woman presenting unilateral panuveitis was later diagnosed with HL. The ocular findings were non-necrotizing scleritis, anterior uveitis, vitritis, white/yellowish chorioretinal lesions, papillitis and vasculitis. A left supra-clavicular lymph node biopsy confirmed the diagnosis of nodular sclerosing Hodgkin's lymphoma stage IIB. Other causes of uveitis were excluded. Chemotherapy led to remission of the disease and the ocular lesions became quiescent with persistent pigmented chorioretinal scars.Hodgkin's lymphoma should be considered in the differential diagnosis of diseases that can occasionally be revealed by unilateral ocular inflammation. A comprehensive, multidisciplinary approach is key to properly assessing such cases.© 2024. The Author(s).