研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

乳香酸的治疗潜力:更新专利审查(2016-2023)。

Therapeutic potential of boswellic acids: an update patent review (2016-2023).

发表日期:2024 Jul 05
作者: Hidayat Hussain, Daijie Wang, Hesham R El-Seedi, Luay Rashan, Ishtiaq Ahmed, Muzaffar Abbas, Nilufar Z Mamadalieva, Haider N Sultani, Muhammad Iftikhar Hussain, Syed Tasadaque A Shah
来源: EXPERT OPINION ON THERAPEUTIC PATENTS

摘要:

乳香酸 (BA) 是一组乌苏烷和齐墩果烷类型的五环三萜类化合物。它们表现出非常有趣的生物学特性,从而导致了许多合成方案的开发。天然 BA 及其合成衍生物均可用于治疗多种癌症、病毒感染和炎症性疾病。本综述涵盖与天然 BA 及其合成衍生物的治疗活性相关的专利。乳香酸的最新专利研究(使用关键词“乳香酸”在 SciFinder、PubMed 和 Google 专利和数据库中总结了 2016 年至 2023 年的乳香酸)。乳香酸已显示出强大的抗病毒、抗癌和抗炎潜力很少有通过 C24-CO2H 官能团修饰制备的 BA 类似物,特别是与母体 AKBA 相比,C-24 酰胺和氨基类似物显示出增强的抗癌作用。此外,这种缀合策略将提高BAs的溶解度和生物利用度,这是BAs开发中最重要的问题之一。
Boswellic acids (BAs) are a group of pentacyclic triterpenoids of the ursane and oleanane type. They have shown very interesting biological properties that have led to the development of a number of synthesis protocols. Both natural BAs and their synthetic derivatives may be useful in the treatment of a variety of cancers, viral infections and inflammatory diseases.This review covers patents relating to the therapeutic activities of natural BAs and their synthetic derivatives. The latest patented studies of boswellic acids (are summarized by using the keywords 'boswellic acid,' in SciFinder, PubMed, and Google Patents and databases in the year from 2016 to 2023.Boswellic acids have shown potent antiviral, anticancer and anti-inflammatory potential. Few BAs analogues have been prepared by modification at the C24-CO2H functional groups. In particular, the C-24 amide and amino analogues have shown enhanced anticancer effects compared to the parent AKBA. In addition, BAs have the ability to form conjugates with other antiviral, anti-inflammatory and anticancer drugs that synergistically enhance their biological efficacy. In addition, this conjugation strategy will increase the solubility and bioavailability of BAs, which is one of the most important issues in the development of BAs.