研究动态
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通过改良化疗和体外膜肺氧合治疗绒毛膜癌综合征引起的睾丸肿瘤和呼吸衰竭一例。

A case of testicular tumor and respiratory failure caused by choriocarcinoma syndrome managed through modified chemotherapy and extracorporeal membrane oxygenation.

发表日期:2024 Jul
作者: Tetsuro Shiraiwa, Hiromichi Katayama, Yudai Iwasaki, Shingo Kimura, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Shinichi Yamashita, Akihiro Ito
来源: Brain Structure & Function

摘要:

伴有多发肺转移的绒毛膜癌综合征预后不良,并因肺泡出血导致呼吸衰竭。我们遇到过一个病例,睾丸肿瘤肺转移灶引入体外膜肺氧合,有效维持氧合直至化疗起效。一名35岁男性,因呼吸困难被转诊至我们医院。他发现左侧睾丸肿瘤伴有多发性肺转移。血清人绒毛膜促性腺激素水平也升高。由于第四天的氧气水平较低,开始减少化疗并进行体外膜肺氧合。化疗成功缩小了肺肿块的大小,并停止了体外膜肺氧合。呼吸状况明显改善,但 4 个月后患者死于脑转移。体外膜氧合可能是治疗绒毛膜癌综合征引起的呼吸衰竭的有效选择,直到通过睾丸肿瘤化疗改善呼吸状况。© 2024 作者。约翰·威利 (John Wiley) 出版的 IJU 病例报告
Choriocarcinoma syndrome with multiple lung metastases has a poor prognosis and causes respiratory failure due to alveolar hemorrhage. We encountered a case where the introduction of extracorporeal membrane oxygenation effectively sustained oxygenation until chemotherapy took effect on lung metastases of testicular tumors.A 35-year-old man with dyspnea was referred to our hospital. He showed left testicular tumor with multiple lung metastases. Serum human chorionic gonadotropin level was also elevated. Reduced chemotherapy was initiated and extracorporeal membrane oxygenation was administered because of low oxygen levels on the fourth day. Chemotherapy successfully reduced the size of the lung masses, and extracorporeal membrane oxygenation was discontinued. Respiratory status improved substantially, but the patient died of brain metastases 4 months later.Extracorporeal membrane oxygenation may be a useful option for managing respiratory failure resulting from choriocarcinoma syndrome until the respiratory condition is improved by chemotherapy for testicular tumors.© 2024 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association.