黑色素瘤是黑色素细胞的恶性肿瘤，由于其侵袭性和高转移潜力，给临床带来了重大挑战。靶向治疗的出现彻底改变了黑色素瘤的治疗格局，特别是对于含有 BRAF V600E 突变等特定基因改变的肿瘤。尽管靶向药物取得了初步成功，但不可避免地会出现耐药性，这凸显了对新治疗策略的需求。本综述探讨了黑色素瘤靶向治疗的最新进展，重点关注新的分子靶点、联合疗法和克服耐药性的策略。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Melanoma, a malignant tumor of melanocytes, poses a significant clinical challenge due to its aggressive nature and high potential for metastasis. The advent of targeted therapy has revolutionized the treatment landscape of melanoma, particularly for tumors harboring specific genetic alterations such as BRAF V600E mutations. Despite the initial success of targeted agents, resistance inevitably arises, underscoring the need for novel therapeutic strategies. This review explores the latest advances in targeted therapy for melanoma, focusing on new molecular targets, combination therapies, and strategies to overcome resistance.Copyright © 2024 Elsevier Inc. All rights reserved.