HPV 被认为是最常见的性传播感染。全球 70% 的宫颈癌都是由它引起的。 HIV 感染与 HPV 感染率增加有关。感染艾滋病毒 (WLWH) 的女性患宫颈癌的风险是普通女性的 6 倍。本研究旨在评估埃及 WLWH 与 HIV 阴性女性相比的 HPV 感染率并确定其基因型，并确定相关危险因素。该研究在初级保健妇科诊所登记的 251 名 WLWH 和 268 名 HIV 阴性女性中进行。来自埃及九个省的护理中心。使用结构化访谈问卷收集参与者的数据，并收集宫颈样本进行 HPV DNA 检测和基因分型。HPV 感染的总体患病率为 13.5%，HIV 阴性女性为 3.4%，WLWH 为 24.4%。从 71% 的感染女性中分离出基因型 16 和 18 以外的 HR-HPV。女性年龄、初婚年龄、终生婚姻次数和吸毒成瘾是 HPV 感染的重要预测因素（赔率分别为 0.96、0.91、2.06、2.01）。HPV 感染在 WLWH 中更为普遍。除基因型 16 和 18 外，HR-HPV 感染在两组感染女性中最为普遍。年轻时、生命早期的性行为、一生中拥有一个以上的性伴侣以及吸毒成瘾是 HPV 感染的独立预测因素。丈夫有其他性伴侣与感染显着相关。© 2024。作者。

HPV is considered the most common sexually transmitted infection. It is responsible of 70% of cervical cancers worldwide. HIV infection is associated with increased rates of HPV infection. Women Living With HIV (WLWH) are 6 times at greater risk of developing cervical cancer. The current study aimed to estimate prevalence and identify genotypes of HPV infection among WLWH in Egypt compared to women with negative HIV status and determine associated risk factors.The study conducted among 251 WLWH and 268 women with negative HIV status enrolled from gynecological clinics in primary health care centers from nine Egyptian governorates. Data was collected from participants using a structured interview questionnaire and cervical samples were collected for HPV DNA detection and genotyping.The overall prevalence of HPV infection was 13.5%, 3.4% among women with HIV negative status and 24.4% among WLWH. HR-HPVs other than genotype 16 and 18 were isolated from 71% of infected women. Woman's age, age at first marriage, number of lifetime marriages and drug addiction are significant predictors for HPV infection (odds 0.96, 0.91, 2.06, 2.01 respectively).HPV infection is more prevalent among WLWH. Infection with HR-HPV other than genotype 16 and 18 was the most prevalent among infected women in both groups. Young age, early life sexual activity, having more than one sexual partner during the life time, and drug addiction are independent predictors for HPV infection. Having a husband who has had other sexual partners is significantly associated with infection.© 2024. The Author(s).