脂肪生成是一个将新脂肪细胞与前体细胞区分开来的过程，并受到多种因素的严格调控，包括许多转录因子和各种翻译后修饰。最近，脂肪生成在各种疾病中发挥了新的作用。然而，这些脂肪形成基因的分子机制和功能调节仍然知之甚少。本文总结了脂肪生成的调节因素和调节剂，并讨论了未来的研究方向，以确定调节脂肪生成的新机制以及脂肪生成调节剂在病理条件下的作用。主要的脂肪形成转录因子 PPARγ 和 C/EBPα 以及其他关键调节因子（例如 SREBP、Kroxs、STAT5、Wnt、FOXO1、SWI/SNF、KLF 和 PARP）均被鉴定。这些转录因子通过特定机制调节脂肪生成，具体取决于脂肪生成阶段。然而，需要进一步研究新发现的脂肪形成调节剂的体内作用及其在各种疾病中的功能，以开发针对代谢疾病和癌症的新的有效治疗策略。版权所有 © 2024 作者。由 Elsevier Masson SAS 出版。保留所有权利。

Adipogenesis is a process that differentiates new adipocytes from precursor cells and is tightly regulated by several factors, including many transcription factors and various post-translational modifications. Recently, new roles of adipogenesis have been suggested in various diseases. However, the molecular mechanisms and functional modulation of these adipogenic genes remain poorly understood. This review summarizes the regulatory factors and modulators of adipogenesis and discusses future research directions to identify novel mechanisms regulating adipogenesis and the effects of adipogenic regulators in pathological conditions. The master adipogenic transcriptional factors PPARγ and C/EBPα were identified along with other crucial regulatory factors such as SREBP, Kroxs, STAT5, Wnt, FOXO1, SWI/SNF, KLFs, and PARPs. These transcriptional factors regulate adipogenesis through specific mechanisms, depending on the adipogenic stage. However, further studies related to the in vivo role of newly discovered adipogenic regulators and their function in various diseases are needed to develop new potent therapeutic strategies for metabolic diseases and cancer.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.