免疫原性细胞死亡（ICD）可以激活免疫系统正常宿主的适应性免疫反应。一些合成化疗药物和天然化合物通过触发损伤相关分子 (DAMP) 的释放来触发 ICD，在癌症治疗中显示出有希望的结果。然而，大多数化疗药物表现出非选择性细胞毒性，还可能诱导和促进转移，从而显着降低其临床疗效。在可诱发ICD的天然化合物中，植物源化合物所占比例最大，其在癌症治疗中的价值越来越大。了解哪些植物源性天然化合物可以诱导 ICD 以及它们如何诱导 ICD 对于制定改善化疗结果的策略至关重要。在这篇综述中，我们重点关注植物源天然化合物根据黄酮类、生物碱、糖苷、萜类化合物的分类诱导ICD的最新发现，并讨论其潜在机制，包括内质网（ER）应激、DNA损伤、细胞凋亡、坏死性凋亡自噬，铁死亡。此外，还阐述了可以增强癌症治疗常规疗法的ICD诱导能力的植物源天然化合物。合理利用植物源天然化合物诱导ICD有助于开发新的癌症治疗方法。版权所有©2024 The Authors。由 Elsevier Masson SAS 出版。保留所有权利。

Immunogenic cell death (ICD) can activate adaptive immune response in the host with normal immune system. Some synthetic chemotherapeutic drugs and natural compounds have shown promising results in cancer treatment by triggering the release of damage-associated molecules (DAMPs) to trigger ICD. However, most chemotherapeutic drugs exhibit non-selective cytotoxicity and may also induce and promote metastasis, thereby significantly reducing their clinical efficacy. Among the natural compounds that can induce ICD, plant-derived compounds account for the largest proportion, which are of increasing value in the treatment of cancer. Understanding which plant-derived natural compounds can induce ICD and how they induce ICD is crucial for developing strategies to improve chemotherapy outcomes. In this review, we focus on the recent findings regarding plant-derived natural compounds that induce ICD according to the classification of flavonoids, alkaloids, glycosides, terpenoids and discuss the potential mechanisms including endoplasmic reticulum (ER) stress, DNA damage, apoptosis, necroptosis autophagy, ferroptosis. In addition, plant-derived natural compounds that can enhance the ICD induction ability of conventional therapies for cancer treatment is also elaborated. The rational use of plant-derived natural compounds to induce ICD is helpful for the development of new cancer treatment methods.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.