五环三萜代表了一类重要的植物生物活性物质，具有多种结构和广泛的生物活性。这些是通过甲羟戊酸途径生物合成产生的，尽管偶尔也可能发生混合途径以引入结构分歧。齐墩果酸是此类化合物中研究最多的生物活性物质之一，具有广泛的药理和生物活性，包括保肝、抗癌、动脉粥样硬化、抗炎、抗菌、抗艾滋病毒、抗氧化、抗衰老等。这篇综述概述了最新的研究成果，强调了齐墩果酸的多功能医学和生物学潜力及其未来前景。版权所有 © 2024 Elsevier Masson SAS。版权所有。

The pentacyclic triterpenes represent a significant class of plant bioactives with a variety of structures and a wide array of biological activities. These are biosynthetically produced via the mevalonate pathway although occasionally mixed pathways may also occur to introduce structural divergence. Oleanolic acid is one of the most explored bioactive from this class of compounds and possesses a broad spectrum of pharmacological and biological activities including liver protection, anti-cancer, atherosclerosis, anti-inflammation, antibacterial, anti-HIV, anti-oxidative, anti-diabetic etc. This review provides an overview of the latest research findings, highlighting the versatile medicinal and biological potential of oleanolic and its future prospects.Copyright © 2024 Elsevier Masson SAS. All rights reserved.