癌症干细胞（CSC）是一小群肿瘤细胞，与较差的预后相关。本研究的目的是评估 ALDH1、CD117、CD133 和 OCT4 的表达； CSC的潜在标志物；及其与诊断为宫颈癌的女性预后的关系。这项回顾性队列研究纳入了 126 名被诊断患有宫颈癌的女性，并通过免疫组织化学对她们的活检进行了分析。标记细胞的中值用于定义低表达和高表达的截止点。对于特定生存率，多变量分析显示淋巴结转移具有统计学意义（HR 8.15；95% CI 3.00-22.18），CD133 高表达具有临界意义（p = 0.058）。对于总生存期，多变量分析显示 IIA-IVB 分期（HR 4.60；95% CI 1.46-14.56）、淋巴结转移（HR 5.13；95% CI 12.02-13.03）和高 CD133 表达（2.67；95% CI）具有统计学意义。 1.11-6.43）。仅考虑患有鳞状细胞癌的女性，在单变量分析中，相同的临床病理学变量与较差的特异性生存率和总生存率相关。然而，CD 133 的表达较高（HR 11.10；95% CI 2.42-50.94 和 6.00；95% CI 2.02-17.87），并且 IIA-IVB 分期（HR 5.96；95% CI 1.30-27.34 和 HR 12.47；95% CI 2.45）正如多变量分析所示，-63.54）分别对特异性生存率和总体生存率产生负面影响。其次，观察到 ALDH1 表达与腺癌相关，CD117 表达与鳞状细胞癌相关。 CD133 的较高表达与较差的特异性和总体生存率相关，表明它可能具有作为临床标志物和治疗靶标的相关性。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Cancer stem cells (CSC), a small population of neoplastic cells, are associated with worse prognosis. The aim of this study was to evaluate the expression of ALDH1, CD117, CD133 and OCT4; potential markers of CSC; and their associations with the prognosis of women diagnosed with cervical cancer. This retrospective cohort study included 126 women diagnosed with cervical cancer whose biopsies were analyzed by immunohistochemistry. Median values of marked cells were used to define cutoff points for low and high expression. For specific survival, multivariate analyses showed statistical significance for lymph node metastases (HR 8.15; 95% CI 3.00-22.18) and borderline significance for high CD133 expression (p = 0.058). For overall survival, multivariate analyses showed statistical significance for IIA-IVB staging (HR 4.60; 95% CI 1.46-14.56), lymph node metastases (HR 5.13; 95% CI 12.02-13.03) and high CD133 expression (2.67; 95% CI 1.11-6.43). Considering only women with SCC, the same clinicopathological variables were associated with worse specific and overall survival in univariate analyses. However, higher expression of CD 133 (HR 11.10; 95% CI 2.42-50.94 and 6.00; 95% CI 2.02-17.87) and staging IIA-IVB (HR 5.96; 95% CI 1.30-27.34 and HR 12.47; 95% CI 2.45-63.54) respectively impacted negatively specific and overall survival, as multivariate analyses showed. Secondarily, it was observed that ALDH1 expression was associated with adenocarcinoma and CD117 expression with squamous cells carcinoma. Higher expression of CD133 was associated with worse specific and overall survival, indicating that it could have relevance as a clinical marker and therapeutic target.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.