急性心肌梗塞 (MI) 等冠状动脉疾病 (CAD) 与癌症有几个共同的危险因素，并且每种疾病都可能影响另一种疾病的预后。最近，急性心肌梗死被证明会加速已有乳腺癌细胞的生长，但心肌梗死后患乳腺癌的风险仍不清楚。本研究旨在调查急性心肌梗死与随后诊断为乳腺癌之间的关联。从台湾全国数据库中识别出有或没有急性心肌梗死病史的女性患者。在研究期间之前诊断出癌症、心肌梗死或冠心病的患者被排除在外。通过治疗加权的逆概率减少混杂因素后，我们比较了有急性心肌梗死病史的患者和没有急性心肌梗死病史的患者之间新诊断乳腺癌的发生率。结果，总共获得了 66,445 名女性患者，其中有 15,263 名有急性心梗病史的患者，51,182 名无急性心梗病史的患者。对于有和没有急性心肌梗死病史的患者，随访期间乳腺癌的发病率分别为每 1000 人年 1.93 例（95% 置信区间 [CI] 1.78-2.09）和 1.80 例（95% CI 1.67-1.93）。 。风险比（HR）为1.05（95% CI 0.78-1.41，P = 0.756）。在亚组分析中，使用抗糖尿病药物的患者（HR 1.27；95% CI 1.02-1.58）和中低城市化水平（HR 1.28；95% CI 1.06-1.53​​）患者的乳腺癌风险与急性心肌梗死显着相关。总之，与没有 MI 或 CAD 的一般人群相比，急性 MI 患者新诊断乳腺癌的风险并未增加。© 2024。作者。

Coronary artery disease (CAD) such as acute myocardial infarction (MI) share several common risk factors with cancers, and each disease may influence the prognosis of the other. Recently, acute MI was demonstrated to accelerate the outgrowth of preexisting breast cancer cells but the risk of breast cancer after MI remains unclear. This study aimed to investigate the association between acute MI and a subsequent diagnosis of breast cancer. Female patients with and without a history of acute MI were identified from nationwide databases in Taiwan. Patients with a diagnosis of cancer, MI or CAD prior to the study period were excluded. After reducing confounding through inverse probability of treatment weighting, we compared the incidence of newly diagnosed breast cancer between patients with a history of acute MI and those without. As a result, a total of 66,445 female patients were obtained, including 15,263 patients with a history of acute MI and 51,182 patients without. The incidences of breast cancer during follow-up were 1.93 (95% confidence interval [CI] 1.78-2.09) and 1.80 (95% CI 1.67-1.93) per 1,000 person-years for patients with and without a history of acute MI, respectively. The hazard ratio (HR) was 1.05 (95% CI 0.78-1.41, P = 0.756). In subgroup analysis, breast cancer risk was significantly associated with acute MI in patients using antidiabetic drugs (HR 1.27; 95% CI 1.02-1.58) and in low to moderate urbanization levels (HR 1.28; 95% CI 1.06-1.53). In conclusion, the risk of newly diagnosed breast cancer was not increased in patients with acute MI when compared to general population without MI or CAD.© 2024. The Author(s).