症状模糊和缺乏特征特征阻碍了儿童脑肿瘤（PBT）的及时诊断。然而，低收入和中等收入国家 (LMIC) 的患者还必须首当其冲地受到导致诊断延迟并随后影响生存的多种其他因素的影响。因此，本研究旨在评估这些因素并量化与中低收入国家 PBT 诊断延迟相关的持续时间。对有关中低收入国家诊断患有脑肿瘤的儿童的现有文献进行了系统回顾。使用 PubMed、Google Scholar、Scopus、Embase、护理和联合健康文献累积索引以及 Web of Science 来识别 2023 年 6 月之前发表的文章。通过 R 统计软件使用随机效应模型进行荟萃分析。使用纽卡斯尔渥太华量表评估质量。共确定了 40 项研究，包括来自 21 个中低收入国家的 2483 名 PBT 患者。总体而言，非特异性症状（62.5%）和社会经济地位（45.0%）是最常报告的导致诊断延迟的因素。与患者相关的延误的潜在来源包括缺乏家长意识（45.0%）和经济限制（42.5%）。导致医疗保健系统延误的因素包括误诊（42.5%）和不当转诊（32.5%）。汇总平均诊断前症状间隔计算为 230.77 天（127.58-333.96），患者相关延迟为 146.02 天（16.47-275.57），医疗保健系统延迟为 225.05 天（-64.79 至 514.89）。多种因素导致中低收入国家诊断延迟。与高收入国家相比，中低收入国家症状出现和 PBT 确诊之间的时间间隔较长，证明了这些因素的影响不成比例。虽然基于证据的政策建议可能会加快诊断速度，但政策制定者需要认识到中低收入国家患者和医疗保健系统面临的独特挑战。版权所有 © 2024 年神经外科医生大会。保留所有权利。

Vague symptoms and a lack of pathognomonic features hinder the timely diagnosis of pediatric brain tumors (PBTs). However, patients in low- and middle-income countries (LMICs) must also bear the brunt of a multitude of additional factors contributing to diagnostic delays and subsequently affecting survival. Therefore, this study aims to assess these factors and quantify the durations associated with diagnostic delays for PBTs in LMICs.A systematic review of extant literature regarding children from LMICs diagnosed with brain tumors was conducted. Articles published before June 2023 were identified using PubMed, Google Scholar, Scopus, Embase, Cumulative Index to Nursing and Allied Health Literature, and Web of Science. A meta-analysis was conducted using a random-effects model through R Statistical Software. Quality was assessed using the Newcastle Ottawa Scale.A total of 40 studies including 2483 patients with PBT from 21 LMICs were identified. Overall, nonspecific symptoms (62.5%) and socioeconomic status (45.0%) were the most frequently reported factors contributing to diagnostic delays. Potential sources of patient-associated delay included lack of parental awareness (45.0%) and financial constraints (42.5%). Factors contributing to health care system delays included misdiagnoses (42.5%) and improper referrals (32.5%). A pooled mean prediagnostic symptomatic interval was calculated to be 230.77 days (127.58-333.96), the patient-associated delay was 146.02 days (16.47-275.57), and the health care system delay was 225.05 days (-64.79 to 514.89).A multitude of factors contribute to diagnostic delays in LMICs. The disproportionate effect of these factors is demonstrated by the long interval between symptom onset and the definitive diagnosis of PBTs in LMICs, when compared with high-income countries. While evidence-based policy recommendations may improve the pace of diagnosis, policy makers will need to be cognizant of the unique challenges patients and health care systems face in LMICs.Copyright © Congress of Neurological Surgeons 2024. All rights reserved.