目的 通过生化参数和组织病理学评分评估赛妥珠单抗对实验性急性胰腺炎（AP）胰腺及靶器官的疗效。 将 40 只雄性 Sprague Dawley 大鼠分为以下 5 个相等的组：第 1 组（假手术组）、第 1 组（假手术组）、第 1 组（假手术组）、第 1 组（假手术组）第2组（AP组）、第3组（AP低剂量赛妥珠单抗组）、第4组（AP高剂量赛妥珠单抗组）和第5组（安慰剂组）。最后一次注射后24小时处死各组大鼠，检测血样中淀粉酶、肿瘤坏死因子α、转化生长因子β、白细胞介素1β、丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶的水平。由对各组不知情的病理学家对胰腺和靶器官（肺、肝、心脏、肾）进行组织病理学研究。还完成了计算机分析。赛妥珠单抗治疗组的生化结果明显优于 AP 组（P < 0.001）。高剂量组（第4组）和低剂量治疗组（第3组）在生化参数和组织病理学评分方面存在显着差异（P < 0.001）。在赛妥珠单抗治疗对靶器官（尤其是肺组织）的影响方面，低剂量治疗组（第3组）和高剂量治疗组（第4组）与AP组（第2组）的差异Certolizumab对AP胰腺及靶器官具有良好的保护作用。它可能是 AP 治疗的有益药物，并且可以预防靶器官损伤。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

It was targeted to assess the efficacy of certolizumab on pancreas and target organs via biochemical parameters and histopathologic scores in experimental acute pancreatitis (AP).Forty male Sprague Dawley rats were divided into the following 5 equal groups: group 1 (sham group), group 2 (AP group), group 3 (AP + low-dose certolizumab group), group 4 (AP + high-dose certolizumab group), and group 5 (placebo group). Rats in all groups were sacrificed 24 hours after the last injection and amylase, tumor necrosis factor α, transforming growth factor β, interleukin 1β, malondialdehyde, superoxide dismutase, and glutathione peroxidase levels were studied in blood samples. Histopathological investigation of both the pancreas and target organs (lungs, liver, heart, kidneys) was performed by a pathologist blind to the groups. In silico analysis were also accomplished.The biochemical results in the certolizumab treatment groups were identified to be significantly favorable compared to the AP group (P < 0.001). The difference between the high-dose group (group 4) and low-dose treatment group (group 3) was found to be significant in terms of biochemical parameters and histopathological scores (P < 0.001). In terms of the effect of certolizumab treatment on the target organs (especially on lung tissue), the differences between the low-dose treatment group (group 3) and high-dose treatment group (group 4) with the AP group (group 2) were significant.Certolizumab has favorable protective effects on pancreas and target organs in AP. It may be a beneficial agent for AP treatment and may prevent target organ damage.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.