胃腺癌（GC）是全球癌症死亡率的第四大原因，也是导致感染相关癌症的主要原因。 GC具有显着的地理差异，在东亚和拉丁美洲山区发病率较高。在美国，GC 的发病率存在显着差异，与非西班牙裔白人相比，西班牙裔的发病率高出 2-3 倍。我们对 2000 年至 2014 年萨尔瓦多的 GC 事件进行了一项全国回顾性研究，以估计年龄通过结合病理学和内窥镜数据库，标准化发病率（ASIR）。卫生部 (MINSAL) 和 ES 胃肠病学会 (AGEDES) 之间形成了一个独特的多部门联盟，代表公立医院 (n=5)、政府雇员医院 (ISSS，n=5) 和私营机构 (n=6) ，占全国内窥镜检查能力的95%以上。 2014-2016 年期间，在代表性样本中确定了 HER2 和 EBV 肿瘤状态。10,039 例独特的 GC 病例被确定，其中 45.5% 为女性，平均年龄为 65 岁。分别有 21% 和 9.4% 的年龄 <55 岁和 <45 岁。 2010 年至 2014 年期间，所有中心均已投入运营，ASIR（M、F）分别为每 10 万人 18.9（95%CI；14.4-20.7）和 12.2（95%CI；10.9-13.5）。肠道GC比弥漫性GC常见2.8倍。 23.2%有部分或完全幽门梗阻。 HER2 2 /3 状态为 16.7%，EBER 阳性率为 10.2%。萨尔瓦多证实胃癌发病率很高，其中近一半患者为女性。研究结果对中美洲 LMIC 的癌症控制和美国拉丁裔人口。

Gastric adenocarcinoma (GC) is the fourth leading cause of global cancer mortality, and leading infection-associated cancer. GC has significant geographic variability, with a high incidence in East Asia and mountainous regions of Latin America. In the U.S., GC represents a marked disparity with incidence rates that are 2-3 times higher in Hispanics compared to non-Hispanic whites.We conducted a national retrospective study of incident GC in El Salvador from to 2000-2014 to estimate the age-standardized incidence rate (ASIR) by using a combination of pathology and endoscopy databases. A unique multisectorial coalition was formed between the Ministry of Health (MINSAL) and ES Gastroenterology Society (AGEDES), representing public hospitals (n=5), governmental employee hospitals (ISSS, n=5), and private facilities (n=6), accounting for >95% of national endoscopy capacity. HER2 and EBV tumor status was ascertained in a representative sample during 2014-2016.10,039 unique cases of GC were identified, 45.5% female, and mean age of 65. 21% and 9.4% were <55 and <45 years old, respectively. ASIRs (M, F) were 18.9 (95%CI;14.4-20.7) and 12.2 per 100,000 persons (95%CI;10.9-13.5), respectively, in the period 2010-2014 with all centers operational. Intestinal GC was 2.8 times more common than diffuse GC. 23.2% had partial or complete pyloric obstruction. The HER2 2+/3+ status was 16.7% and EBER positivity was 10.2%.A high incidence of gastric cancer was confirmed in El Salvador, and nearly half of patients were female.The findings have implications for cancer control in the Central America LMICs and for U.S. Latino populations.