超氧化物歧化酶 (SOD) 是一种在保护细胞免受氧化损伤方面发挥着关键作用的酶。我们的研究旨在解决缺乏同时分析人外分泌胰腺细胞中所有三种不同 SOD 亚型免疫反应性的论文的问题。超氧化物歧化酶 (SOD) 有助于将超氧自由基转化为危害较小的物质。通过中和超氧自由基，SOD 有助于防止高反应性和破坏性物质的形成，这些物质会对多种细胞成分产生不利影响。该研究在光学显微镜下使用间接免疫组织化学方法分析了六个健康成年人胰腺样本中 SOD 的免疫反应性。 SOD1主要存在于腺泡中心细胞和导管系统上皮细胞中，而SOD2主要存在于小叶间导管上皮细胞中。这两种酶主要存在于靠近细胞核的腺泡细胞的基底区域。 SOD3 的表达很少见。了解健康外分泌胰腺细胞中 SOD 的细胞内代谢，可以为确定氧化损伤和 SOD 信号传导在各种胰腺疾病（包括慢性胰腺炎和胰腺癌）发病机制中的精确作用奠定基础（图 6，参考文献 24）。 PDF 文本 www.elis.sk 关键词：抗氧化剂、组织学、免疫组织化学、胰腺、超氧化物歧化酶。

Superoxide dismutase (SOD) is an enzyme that plays a crucial role in protecting cells from oxidative damage. Our study aims to address the lack of papers simultaneously analyzing the immunoreactivity of all three distinct isoforms of SOD in human exocrine pancreas cells.Superoxide dismutases (SODs) facilitate the conversion of superoxide radicals into less harmful substances. By neutralizing superoxide radicals, SODs help prevent the formation of highly reactive and destructive species that can adversely affect manifold cellular components.The study analyzed immunoreactivity of SODs in samples of six healthy adult human pancreases, while using the indirect immunohistochemical method under a light microscope.SOD1 was predominantly found in centroacinar cells and epithelial cells of the duct system while SOD2 was mainly detected in the epithelial cells of interlobular ducts. Both enzymes were prominently present in the basal region of acinar cells near the cell nucleus. The expression of SOD3 was observed to be rare.Understanding the intracellular metabolism of SODs in healthy exocrine pancreas cells serves as a basis for determining the precise role of oxidative damage and SOD signaling in the pathogenesis of various pancreatic diseases, including chronic pancreatitis and pancreatic cancer (Fig. 6, Ref. 24). Text in PDF www.elis.sk Keywords: antioxidants, histology, immunohistochemistry, pancreas, superoxide dismutase.