Netrin-1 及其受体在神经元发育过程中诱导轴突生长和神经元迁移中发挥着至关重要的作用。它们的深远影响延伸到成年期，包括神经元存活和突触功能的维持。越来越多的证据强调了几个关键点：(1) Netrin-1 水平降低会加剧阿尔茨海默病和帕金森病动物模型的病理进展，并且可能在人类中发生类似的变化。 (2) Netrin-1 受体的基因突变会增加个体对神经退行性疾病的易感性。 (3) 针对 Netrin-1 及其受体的治疗方法具有增强记忆和运动功能的益处。 (4) Netrin-1 及其受体在多种癌症中表现出遗传和表观遗传改变。这些发现提供了令人信服的证据，证明 Netrin-1 及其受体是神经退行性疾病的关键靶点。通过对 Netrin-1 信号通路的全面回顾，我们的目标是发现神经退行性疾病的潜在治疗途径。版权所有 © 2025 版权所有：© 2025 神经再生研究。

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development. Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function. Increasing amounts of evidence highlight several key points: (1) Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer's disease and Parkinson's disease, and potentially, similar alterations occur in humans. (2) Genetic mutations of Netrin-1 receptors increase an individuals' susceptibility to neurodegenerative disorders. (3) Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function. (4) Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers. These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases. Through a comprehensive review of Netrin-1 signaling pathways, our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.