慢性疼痛仍然是一个严重的健康问题，对发病率和健康产生重大影响。现有的治疗方法仅产生相对有限的疗效。因此，具有不同机制的新型治疗方法最近引起了经验兴趣。据推测，利多卡因通过作用于 N-甲基-D-天冬氨酸 (NMDA) 和电压门控钙受体来提供抗炎和抗伤害作用。新兴研究表明利多卡因可能是治疗慢性疼痛的合理替代品。考虑到利多卡因作为慢性疼痛治疗方式的潜力的证据，我们对利多卡因治疗慢性疼痛的证据进行了叙述性回顾。PubMed 的回顾和谷歌学术数据库于 2022 年 5 月进行，以识别已完成的研究，这些研究调查了从数据库建立到 2022 年 6 月利多卡因治疗慢性疼痛的有效性。叙述性综述中总共纳入了 25 项研究。现有研究结果表明，静脉输注利多卡因是一种新兴且有前途的选择，可以减轻某些临床人群的疼痛。我们的叙述综合表明，目前静脉注射利多卡因治疗多种慢性疼痛综合征的证据是混杂的。研究结果表明，对于 CRPS 和癌痛的疗效证据有限。然而，有充分的证据支持静脉注射利多卡因可增强慢性术后疼痛的功效。利多卡因可能是治疗慢性疼痛的一种有前途的药理学解决方案。未来的研究有必要阐明利多卡因减弱疼痛信号通路的神经生物学机制。版权所有 © 1964–2024，加利福尼亚州洛杉矶 MedWorks Media Inc，保留所有权利。美国印刷。

Chronic pain remains a serious health problem with significant impact on morbidity and well-being. Available treatments have only resulted in relatively modest efficacy. Thus, novel therapeutic treatments with different mechanisms have recently generated empirical interest. Lidocaine is postulated to provide anti-inflammatory and anti-nociceptive effect through its action at the N-methyl-D-aspartate (NMDA) and voltage gated calcium receptors. Emerging research indicates that lidocaine could be a reasonable alternative for treating chronic pain.Considering the evidence surrounding lidocaine's potential as a therapeutic modality for chronic pain, we conducted a narrative review on the evidence of lidocaine's therapeutic effects in chronic pain.A review of the PubMed, and Google scholar databases was undertaken in May 2022 to identify completed studies that investigated the effectiveness of lidocaine in the treatment of chronic pain from database inception to June 2022.A total of 25 studies were included in the narrative review. Findings on available studies suggest that intravenous infusion of lidocaine is an emerging and promising option that may alleviate pain in some clinical populations. Our narrative synthesis showed that evidence for intravenous lidocaine is currently mixed for a variety of chronic pain syndromes. Findings indicate that evidence for efficacy is limited for: CRPS, and cancer pain. However, there is good evidence supporting the efficacy of intravenous lidocaine as augmentation in chronic post-surgical pain.Lidocaine may be a promising pharmacologic solution for chronic pain. Future investigation is warranted on elucidating the neurobiological mechanisms of lidocaine in attenuating pain signaling pathways.Copyright © 1964–2024 by MedWorks Media Inc, Los Angeles, CA All rights reserved. Printed in the United States.