铁死亡是近年来提出的一种新型程序性细胞死亡，其主要特征是活性氧和铁介导的脂质过氧化，与细胞凋亡、坏死、自噬等程序性细胞死亡不同。铁死亡与多种生理和病理生理过程相关。最新研究表明，铁死亡可以通过靶向肿瘤、缺血性器官损伤以及其他与脂质过氧化相关的退行性疾病中的代谢途径和信号通路，从而加重或减轻疾病的发生和发展。越来越多的证据表明，铁死亡与各种眼科疾病的发生和进展密切相关，包括角膜损伤、青光眼、年龄相关性黄斑变性、糖尿病性视网膜病变、视网膜脱离和视网膜母细胞瘤。我们对当前眼科疾病铁死亡研究的回顾揭示了我们对这些疾病的发病机制、病因学和治疗的理解取得了重大进展。版权所有 © 2024 Yang、Lin、Han、Wang、Zheng 和 Wei。

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.Copyright © 2024 Yang, Lin, Han, Wang, Zheng and Wei.