基于生物信息学分析探讨GAB2在泛癌中的作用。基于TCGA和GTEx数据库，利用TIMER2.0在线分析工具和R语言分析GAB2在泛癌中的表达。我们使用Kaplan-Meier Plotter分析了泛癌中GAB2与OS和RFS之间的关系。我们利用 CPTAC 数据库检查泛癌中磷酸化 GAB2 的表达。我们通过cBioPortal和COSMIC研究了突变特征对人类癌症发生和发展的影响。利用该数据库，我们对可能通过分子对接与 GAB2 相互作用的分子化合物进行了分析。此外，我们使用TIMER探索GAB2与免疫细胞浸润的关系，并通过R语言绘制相关热图。GAB2在多种肿瘤中异常表达并与预后相关。不同类型肿瘤的肿瘤组织及相应正常组织中GAB2磷酸化表达存在差异。 GAB2与多西紫杉醇相互作用，并与多种肿瘤中的免疫细胞浸润相关。GAB2参与调节免疫浸润并影响患者的预后。 GAB2 可作为潜在的肿瘤标志物。© 2024。作者。

To explore the role of GAB2 in pan-cancer based on bioinformatics analysis.Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer. We used Kaplan-Meier Plotter to analyze the relationship between GAB2 and OS and RFS in pan-cancer. We utilized the CPTAC database to examine the expression of phosphorylated GAB2 in pan-cancer. We investigated the effects of mutation features on the occurrence and development of human cancers by cBioPortal and COSMIC. Using the database, we conducted an analysis of molecular compounds that have the potential to interact with GAB2 through molecular docking. Moreover, we use the TIMER to explore the relationship between GAB2 and immune cell infiltration, and draw relevant heatmaps by R language.GAB2 was abnormally expressed in various tumors and was associated with prognosis. There were differences in the expression of GAB2 phosphorylation in tumor tissues and corresponding normal tissues among different types of tumors. GAB2 interacts with Docetaxel and was associated with immune cell infiltration in various tumors.GAB2 participates in regulating immune infiltration and affects the prognosis of patients. GAB2 may serve as a potential tumor marker.© 2024. The Author(s).