癌症相关营养不良与更差的症状严重程度、功能状态、生活质量和总体生存率相关。癌症患者的营养不良往往未被充分认识和治疗，这强调了该人群需要标准化的营养管理途径。本研究的目的是（1）调查成人肿瘤门诊人群中营养不良风险与自我报告症状严重程度评分之间的关​​系，以及（2）确定是否应使用营养不良风险二级筛查工具（abPG-SGA）推荐用于具有特定 ESAS-r 截止分数或 ESAS-r 截止分数组的患者。进行了单机构回顾性横断面研究。使用简化的患者主观总体评估 (abPG-SGA) 来衡量营养不良风险。使用修订版埃德蒙顿症状评估系统（ESAS-r）测量癌症症状的严重程度。根据标准机构惯例，患者在癌症中心首次咨询时完成了这两种工具。纳入2017年2月至2020年1月期间同一天完成ESAS-r和abPG-SGA的成年患者。使用Spearman相关性、Mann Whitney U检验、接受者操作特征曲线和二元逻辑回归模型进行统计分析。2071名肿瘤门诊患者符合纳入标准（平均年龄65.7岁），其中33.6%被确定有营养不良的风险。对于所有 ESAS-r 参数（疼痛、疲倦、嗜睡、恶心、食欲不振、气短、抑郁、焦虑和健康），有营养不良风险的患者得分显着较高（P<0.001）。所有ESAS-r参数均与abPG-SGA评分呈正相关（P < 0.01）。最能预测营养不良风险状态的 ESAS-r 参数是 ESAS-r 总分、食欲不振、疲劳和健康（曲线下面积分别为 0.824、0.812、0.764、0.761）。缺乏食欲评分 ≥ 1 的敏感性为 77.4%，特异性为 77.0%。将食欲缺乏评分 ≥ 1与总ESAS评分 > 14相结合，得出的敏感性为87.9%，特异性为62.8%。abPG-SGA测量的营养不良风险与ESAS-r测量的症状严重程度评分呈正相关且显着相关。鉴于 ESAS-r 在癌症护理中的广泛使用，利用特定的 ESAS-r 截止点来触发营养不良筛查可能是识别有营养不良风险的癌症患者的可行方法。© 2024。作者。

Cancer-associated malnutrition is associated with worse symptom severity, functional status, quality of life, and overall survival. Malnutrition in cancer patients is often under-recognized and undertreated, emphasizing the need for standardized pathways for nutritional management in this population. The objectives of this study were to (1) investigate the relationship between malnutrition risk and self-reported symptom severity scores in an adult oncology outpatient population and (2) to identify whether a secondary screening tool for malnutrition risk (abPG-SGA) should be recommended for patients with a specific ESAS-r cut-off score or group of ESAS-r cut-off scores.A single-institution retrospective cross-sectional study was conducted. Malnutrition risk was measured using the Abridged Patient-Generated Subjective Global Assessment (abPG-SGA). Cancer symptom severity was measured using the Revised Edmonton Symptom Assessment System (ESAS-r). In accordance with standard institutional practice, patients completed both tools at first consult at the cancer centre. Adult patients who completed the ESAS-r and abPG-SGA on the same day between February 2017 and January 2020 were included. Spearman's correlation, Mann Whitney U tests, receiver operating characteristic curves, and binary logistic regression models were used for statistical analyses.2071 oncology outpatients met inclusion criteria (mean age 65.7), of which 33.6% were identified to be at risk for malnutrition. For all ESAS-r parameters (pain, tiredness, drowsiness, nausea, lack of appetite, shortness of breath, depression, anxiety, and wellbeing), patients at risk for malnutrition had significantly higher scores (P < 0.001). All ESAS-r parameters were positively correlated with abPG-SGA score (P < 0.01). The ESAS-r parameters that best predicted malnutrition risk status were total ESAS-r score, lack of appetite, tiredness, and wellbeing (area under the curve = 0.824, 0.812, 0.764, 0.761 respectively). Lack of appetite score ≥ 1 demonstrated a sensitivity of 77.4% and specificity of 77.0%. Combining lack of appetite score ≥ 1 with total ESAS score > 14 yielded a sensitivity of 87.9% and specificity of 62.8%.Malnutrition risk as measured by the abPG-SGA and symptom severity scores as measured by the ESAS-r are positively and significantly correlated. Given the widespread use of the ESAS-r in cancer care, utilizing specific ESAS-r cut-offs to trigger malnutrition screening could be a viable way to identify cancer patients at risk for malnutrition.© 2024. The Author(s).