使用 3D 适形放射治疗 (3DCRT)、调强放射治疗 (IMRT) 和快速弧法对左乳放射进行剂量测定和放射生物学特征验证和使用最佳治疗方法。使用定制的 Python 软件来估计和比较体积、平均剂量、最大剂量、监测单位和正常组织积分剂量以及放射生物学参数，例如 NTCP、肿瘤控制概率、等效均匀剂量和来自 3DCRT 的 LKB 有效体积、IMRT 和快速弧计划，采用屏气 (DIBH) 和自由宽度 (FB) 技术进行深吸气。与 FB 相比，DIBH 的体积增长了四分之三，导致心脏剂量和并发症的减少，因为左肺扩张，将心脏拉离胸壁和治疗区域。在治疗过程中，左肺的一小部分区域被暴露，这减少了平均剂量。治疗方法几乎没有差异，因为两种技术中脊髓都是固定的。快速弧是一种无与伦比的左侧乳房照射方式，患者需屏气，通过比较深吸气屏气方法的治疗技术的剂量学和放射生物学参数即可看出。© 作者 2024 年。已发布牛津大学出版社。版权所有。如需权限，请发送电子邮件至：journals.permissions@oup.com。

The verification and use of the best treatment approach using 3D conformal radiation therapy (3DCRT), intensity modulated radiation therapy (IMRT) and Rapid Arc methods for left breast radiation with dosimetric and radiobiological characteristics. The use of custom-built Python software for the estimation and comparison of volume, mean dose, maximum dose, monitor units and normal tissue integral dose along with radiobiological parameters such as NTCP, tumor control probability, equivalent uniform dose and LKB's effective volume from 3DCRT, IMRT and Rapid Arc planning with deep inspiration with breath holding (DIBH) and free breadth (FB) techniques. Volume growth of three-fourth in DIBH compared with FB causes a decrease in cardiac doses and complications because the left lung expands, pulling the heart away from the chest wall and the treatment area. A tiny area of the left lung was exposed during treatment, which reduced the mean dose. There was little difference in the treatment approaches because the spinal cord was immobile in both techniques. Rapid Arc is the unmatched modality for left-sided breast irradiation with significant patient breath-hold, as shown by the comparison of dosimetric and radiobiological parameters from treatment techniques with a deep inspiration breath-hold approach.© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.