这项关于醉鱼草的研究强调了其植物化学成分、抗菌活性和细胞毒性影响。该研究通过 GC-MS 分析鉴定了参与生物活性的重要化合物，强调了该植物治疗眼部疾病的潜力。本研究探讨了醉鱼草（茎和叶）提取物的抗菌和细胞毒性潜力，重点是其在治疗细菌性眼部感染中的应用及其对 MCF7、HT29 和 HepG2 癌细胞的功效。通过全面的 GC-MS 分析，在醉鱼草茎叶提取物中鉴定出多种植物化学物质，包括碳水化合物、酚类衍生物、脂肪酸和甾体成分。然后对提取物的生物活性进行了评估，结果显示其对一系列与眼部感染有关的细菌菌株具有显着的抗菌特性。研究结果表明，来自醉鱼草的茎提取物对癌细胞系 MCF7、HT29 和 HepG2 表现出高至中度的细胞毒性作用。值得注意的是，这些效应的特征是不同的 IC50 值，这表明不同的敏感性水平。相比之下，当针对所有这些细胞系进行测试时，叶提取物表现出降低的细胞毒性，尽管它们对 agonist HepG2 细胞的细胞毒性显着较高。这项研究的结果强调了醉鱼草提取物在治疗眼部感染和癌症方面的潜在治疗用途。这些结果表明需要进行额外的研究来阐明这些提取物的潜在作用机制并探索它们作为药物的潜力。© 2024。作者。

This study on Buddleja polystachya highlights its phytochemical composition, antimicrobial activity, and cytotoxic impacts. The study emphasizes the plant's potential to treat ocular diseases by identifying important compounds involved in the bioactivity through GC-MS analysis. This study explores the antimicrobial and cytotoxic potential of Buddleja polystachya (stem and leaves) extracts, with a focus on their application in treating bacterial ocular infections and their efficacy against MCF7, HT29, and HepG2 cancer cells. Through comprehensive GC-MS analysis, a diverse array of phytochemicals was identified within Buddleja polystachya stem and leaves extracts, including carbohydrates, phenolic derivatives, fatty acids, and steroidal components. The extracts were then evaluated for their biological activities, revealing significant antimicrobial properties against a range of bacterial strains implicated in ocular infections. The research findings demonstrate that stem extracts derived from Buddleja polystachya demonstrated high to moderate cytotoxic effects on cancer cell lines MCF7, HT29, and HepG2. Notably, these effects were characterized by varying IC50 values, which suggest distinct levels of sensitivity. In contrast, leaf extracts exhibited reduced cytotoxicity when tested against all these cell lines, although they did so with a significantly higher cytotoxicity aganist HepG2 cells. The results of this investigation highlight the potential therapeutic utilization of Buddleja polystachya extracts in the management of ocular infections and cancer. These results support the need for additional research to elucidate the underlying mechanisms of action of these extracts and explore their potential as drugs.© 2024. The Author(s).