银屑病和银屑病关节炎研究与评估小组 (GRAPPA) 2023 年年会基础科学研讨会强调了银屑病 (PsD) 的当代转化和临床研究进展。今年的研讨会重点讨论了关键主题，包括年度 GRAPPA 会议作为协作和知识交流平台的重要性。讨论的重点是扩大我们对 PsD 肿瘤坏死因子抑制剂 (TNFi) 治疗的理解，并加强 PsD 合并症的早期检测策略，特别是及时干预和管理心血管 (CV) 合并症。提供了关于 C-C 趋化因子受体 6 型 (CCR6) 在 PsD 和银屑病关节炎中的作用的见解，表明阻断 CCR6 可以减少小鼠模型中的银屑病样皮炎和关节炎症。

Contemporary translational and clinical research advances in psoriatic disease (PsD) were highlighted at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting basic science workshop. This year's workshop focused on key topics, including the significance of the annual GRAPPA meetings as a platform for collaboration and knowledge exchange. Discussions centered around expanding our understanding of tumor necrosis factor inhibitor (TNFi) treatment in PsD and enhancing early detection strategies for PsD comorbidities, specifically for the timely intervention and management of cardiovascular (CV) comorbidities. Insights on the role of the C-C chemokine receptor type 6 (CCR6) in PsD and psoriatic arthritis were provided, suggesting that blockade of CCR6 can reduce psoriasis-like dermatitis and joint inflammation in mouse models.