了解乳酸在乙型肝炎病毒相关肝细胞癌发展中的作用。
Understanding lactate in the development of Hepatitis B virus-related hepatocellular carcinoma.
发表日期:2024 Jul 15
作者:
Sheida Behzadi Sheikhrobat, Shahab Mahmoudvand, Salva Kazemipour-Khabbazi, Zahra Ramezannia, Hossein Bannazadeh Baghi, Somayeh Shokri
来源:
Epigenetics & Chromatin
摘要:
乙型肝炎病毒 (HBV) 是一种嗜肝病毒,可在人类中造成持续性慢性感染。慢性乙型肝炎 (CHB) 感染与肝功能失代偿、肝硬化和肝细胞癌 (HCC) 的风险增加相关。乳酸水平作为糖酵解的最终产物,在能量产生之外的新陈代谢中发挥着重要作用。新兴研究表明,乳酸与患者死亡率有关,并且 HBV 会增加肝细胞的总体葡萄糖消耗和乳酸生成。过量的乳酸在调节肿瘤微环境(TME)、免疫细胞功能、自噬和表观遗传重编程中发挥着作用。本综述的目的是收集和总结关于乳酸在免疫系统失调中的功能的现有知识,乳酸在 HBV 相关 HCC 的发展中发挥着至关重要的作用。因此,可以合理地假设具有有趣功能的乳酸可以被视为免疫治疗中的免疫调节代谢物。© 2024。作者。
Hepatitis B Virus (HBV) is a hepatotropic virus that can establish a persistent and chronic infection in humans. Chronic hepatitis B (CHB) infection is associated with an increased risk of hepatic decompensation, cirrhosis, and hepatocellular carcinoma (HCC). Lactate level, as the end product of glycolysis, plays a substantial role in metabolism beyond energy production. Emerging studies indicate that lactate is linked to patient mortality rates, and HBV increases overall glucose consumption and lactate production in hepatocytes. Excessive lactate plays a role in regulating the tumor microenvironment (TME), immune cell function, autophagy, and epigenetic reprogramming. The purpose of this review is to gather and summarize the existing knowledge of the lactate's functions in the dysregulation of the immune system, which can play a crucial role in the development of HBV-related HCC. Therefore, it is reasonable to hypothesize that lactate with intriguing functions can be considered an immunomodulatory metabolite in immunotherapy.© 2024. The Author(s).