细胞焦亡是一种与免疫系统相关的程序性细胞死亡的炎症形式，可由活性氧 (ROS) 诱导。作为一种具有更好穿透深度的治疗策略，声动力疗法（SDT）有望诱导癌细胞焦亡并增强免疫反应。然而，精确调整声敏剂的结构以表现出令人满意的声催化性能仍然是一个有限的问题。在此，开发了氟化二氧化钛 (TiO2-xFx) 声敏剂，用于在超声 (US) 下诱导细胞焦亡，以增强抗肿瘤免疫反应，从而实现高效的 SDT。一方面，F原子的引入显着降低了TiO2-xFx对氧和水的吸附能，有利于声催化反应的发生。另一方面，F取代O的过程增加了声敏剂的氧空位并缩短了带隙，从而在US刺激下具有强大的ROS生成能力。在这种情况下，大量的ROS可以通过诱导线粒体损伤和破坏氧化稳态来有效杀死癌细胞，从而导致显着的细胞焦亡。此外，使用 TiO2-xFx 进行 SDT 治疗不仅可以抑制肿瘤增殖，还可以引发强大的免疫记忆效应并阻止肿瘤复发。这项工作强调了精确调节声敏剂结构以实现高效 ROS 生成以诱导细胞焦亡的重要性，这为 SDT 免疫疗法的进一步发展奠定了基础。

Pyroptosis is an inflammatory form of programmed cell death associated with the immune system that can be induced by reactive oxygen species (ROS). As a therapeutic strategy with better penetration depth, sonodynamic therapy (SDT) is expected to induce pyroptosis of cancer cells and boost the immune response. However, it is still a limited problem to precisely adjust the structure of sonosensitizers to exhibit satisfactory sono-catalytic properties. Herein, fluorinated titanium oxide (TiO2-xFx) sonosensitizers were developed to induce pyroptosis under ultrasound (US) to boost antitumor immune responses, enabling highly effective SDT. On the one hand, the introduction of F atoms significantly reduced the adsorption energy of TiO2-xFx for oxygen and water, which is conducive to the occurrence of sono-catalytic reactions. On the other hand, the process of F replacing O increased the oxygen vacancies of the sonosensitizer and shortened the band gap, which enabled powerful ROS generation ability under US stimulation. In this case, large amounts of ROS could effectively kill cancer cells by inducing mitochondrial damage and disrupting oxidative homeostasis, leading to significant cell pyroptosis. Moreover, SDT treatment with TiO2-xFx not only suppressed tumor proliferation but also elicited robust immune memory effects and hindered tumor recurrence. This work highlighted the importance of precisely regulating the structure of sonosensitizers to achieve efficient ROS generation for inducing pyroptosis, which sets the stage for the further development of SDT-immunotherapy.