半夹心 Ru(II)-p-伞花烯亚硝酸盐复合物选择性诱导顺铂耐药的恶性黑色素瘤细胞死亡。
A half sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.
发表日期：2024 Jul 16
作者：
Yin-Hsuan Sun, Huey-Ling You, Manmath Narwane, Ru Xin Koi, Chai-Lin Kao, Shyng-Shiou F Yuan, Wei-Ting Liao, Tsai-Te Lu, Sodio C N Hsu
来源：
Cell Death & Disease
摘要：
Ru(II)-亚硝酸盐复合物 Ru4 可在酸性条件下释放一氧化氮 (NO)，并选择性诱导对 SK-MEL-28 顺铂耐药的恶性黑色素瘤细胞的细胞毒性作用。这些发现表明，针对肿瘤相关 pHe 水平可能是发挥亚硝酸钌化合物药物功能的有效策略。
The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.