甜菜变种crassa无疑是一种非常重要的植物，但在世界上尚未得到足够的利用。在本研究中，目的是确定甜菜叶部分中发现的成分（精油、脂肪酸、总酚和类黄酮）的细胞毒活性。 crassa 针对 PC-3、MCF-7 和 HeLa 癌细胞系。此外，还测试了这些成分对抗可能导致人类严重健康问题的细菌和真菌的有效性。在实验中，将三种肿瘤细胞系暴露于不同植物提取物浓度（31.25、62.5、125、250、500 和 1000 µg/mL）中 72 小时。结果发现，植物提取物对 PC-3 细胞表现出高（SI：2.14 > 2）细胞毒性，对 HeLa 细胞表现出中度（SI：1.62 < 2）细胞毒性，对 MCF-7 细胞表现出低（SI：0.93 < 2）细胞毒性。此外，不同植物提取物浓度对金黄色葡萄球菌、化脓性链球菌和痤疮皮肤杆菌的抑制率为16.3-22.3%、16.8-23.5%和12-16.2%。同样，白色念珠菌的抑制率为 9.5-20.7%，耳念珠菌为 3.5-7.7%，光滑念珠菌为 5.5-15.1%。结果表明，植物提取物对癌细胞系和微生物病原体表现出浓度依赖性细胞毒性和抗菌作用。在线版本包含补充材料，请访问 10.1007/s12088-024-01269-8。© 印度微生物学家协会 2024 Springer Nature 或其许可方（例如协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议拥有本文的专有权；作者对本文已接受的手稿版本的自行存档仅受此类出版协议和适用法律的条款的约束。

Beta vulgaris var. crassa is undoubtedly a very important plant that is not used enough in the world. In this study, it was aimed to determine the cytotoxic activities of the components (essential oils, fatty acids, total phenol and flavonoid) found in the leaf parts of Beta vulgaris var. crassa against PC-3, MCF-7 and HeLa cancer cell lines. In addition, the effectiveness of these ingredients against bacteria and fungi that can cause serious health problems in humans was tested. In experiments, three tumor cell lines were exposed to various plant extract concentrations (31.25, 62.5, 125, 250, 500 and 1000 µg/mL) for 72 h. It was found that plant extracts showed high (SI: 2.14 > 2) cytotoxicity to PC-3 cells, moderate (SI: 1.62 < 2) to HeLa cells, and low (SI: 0.93 < 2) cytotoxicity to MCF-7 cells. Also, different plant extract concentrations were found to cause an inhibition rate of 16.3-22.3% in Staphylococcus aureus, 16.8-23.5% in Streptococcus pyogenes and 12-16.2% in Cutibacterium acnes. Similarly, inhibition rates were determined between 9.5-20.7% for Candida albicans, 3.5-7.7% for Candida auris, and 5.5-15.1% for Candida glabrata. The results showed that the plant extract exhibited a concentration-dependent cytotoxic and antimicrobial effect against both cancer cell lines and microbial pathogens.The online version contains supplementary material available at 10.1007/s12088-024-01269-8.© Association of Microbiologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.