我们前瞻性地分析了女性空腹血糖（FPG）与乳腺癌风险之间的相关性；探讨女性乳腺癌的独立危险因素，并比较 FPG 水平对年轻和非年轻乳腺癌风险的影响。我们的研究为我国乳腺癌病因学研究提供了新的证据和思路，提高了乳腺癌二级预防的准确性，为乳腺癌合并糖尿病患者的临床诊治提供了选择。 参与第一期的三组女性汇总开滦集团2006年、2008年、2010年健康体检数据，对FPG基线数据进行描述性分析。采用Kaplan-Meier法计算不同组13年乳腺癌累积发病率，并采用时序检验进行组间比较。采用Cox比例风险回归模型分析FPG水平与乳腺癌风险的相关性。FPG高于5.29 mmol/L人群乳腺癌累积发病率增加，但对FPG水平的影响无显着性差异。不同水平的FPG对人群中年轻乳腺癌风险的影响。不同程度的空腹血糖可影响人群中非年轻乳腺癌的风险。本研究结果提示，通过早期干预控制FPG水平可以逆转乳腺癌风险。定期监测 FPG 可降低人群乳腺癌误诊率。版权所有 © 2024 Li、Yin、Fan、Qu。

We prospectively analyzed the correlation between fasting plasma glucose (FPG) and the risk of breast cancer in women; explored the independent risk factors for breast cancer in women, and compared the effect of FPG level on the risk of young and non-young breast cancer. Our study provides new evidence and ideas for research into breast cancer etiology in China, improves the accuracy of secondary prevention of breast cancer, and provides options for the clinical diagnosis and treatment of breast cancer patients with diabetes.Three cohorts of women participating in the first health examination of the Kailuan Group in 2006, 2008 and 2010 were assembled to conduct a descriptive analysis of the baseline data on FPG. The cumulative incidence of breast cancer in different groups over 13 years was calculated using the Kaplan-Meier method and groups were compared using the log-rank test. A Cox proportional hazards regression model was used to analyze the association between FPG level and the risk of breast cancer.The cumulative incidence of breast cancer increased in people with FPG higher than 5.29 mmol/L, but there was no significant difference in the effect of different levels of FPG on the risk of young breast cancer in the population. Different degrees of fasting glucose can affect the risk of non-young breast cancer in the population.The results of this study suggest that the risk of breast cancer can be reversed by early intervention to control levels of FPG. Regular monitoring of FPG may reduce the misdiagnosis rate of breast cancer in the population.Copyright © 2024 Li, Yin, Fan and Qu.