细胞免疫疗法是一种创新的癌症治疗方法，利用患者自身的免疫系统有效对抗肿瘤细胞。目前主流的治疗方法包括嵌合抗原受体T细胞（CAR-T）疗法、T细胞受体基因修饰T细胞疗法和嵌合抗原受体自然杀伤细胞疗法，其中CAR-T疗法最为先进。尽管如此，这种疗法的传统制造工艺在每个步骤中都存在缺陷，需要改进。人们在其增强方面投入了显着的努力，同时在生物材料应用领域取得了显着的进展。以CAR-T疗法为例，本文旨在全面讨论细胞免疫疗法中使用的各种生物材料、它们在调节免疫细胞中的作用，以及它们在癌症治疗从基因转导到疗效增强方面的突破潜力。本文还讨论了广泛采用的用于功效评估的动物模型。版权所有 © 2024 Gauyu Yu 等人。

Cellular immunotherapy is an innovative cancer treatment method that utilizes the patient's own immune system to combat tumor cells effectively. Currently, the mainstream therapeutic approaches include chimeric antigen receptor T cell (CAR-T) therapy, T cell receptor gene-modified T cell therapy and chimeric antigen receptor natural killer-cell therapy with CAR-T therapy mostly advanced. Nonetheless, the conventional manufacturing process of this therapy has shortcomings in each step that call for improvement. Marked efforts have been invested for its enhancement while notable progresses achieved in the realm of biomaterials application. With CAR-T therapy as a prime example, the aim of this review is to comprehensively discuss the various biomaterials used in cell immunotherapy, their roles in regulating immune cells, and their potential for breakthroughs in cancer treatment from gene transduction to efficacy enhancement. This article additionally addressed widely adopted animal models for efficacy evaluating.Copyright © 2024 Gaoyu Yu et al.