本研究调查了芝麻素对顺铂 (CP) 引起的急性肾脏和睾丸损伤的肾单位睾丸保护作用。32 只雄性 Wistar 大鼠被分配接受羧甲基纤维素（0.5%，作为芝麻素载体）、CP（单次腹腔注射）。 5mg/kg剂量），CP加芝麻素10或20mg/kg口服，连续10天。数据分析显示血清尿素、肌酐、白细胞介素（IL）-1、IL-6和肿瘤坏死因子-α显着升高与对照动物相比，CP 中毒大鼠的 (TNF-α) 以及肾和睾丸组织丙二醛和一氧化氮浓度。相反，与对照大鼠相比，用 CP 治疗的大鼠仅表现出显着较低 (p < .05) 的血清睾酮、组织谷胱甘肽和内源性抗氧化酶活性。使用 H 进行组织病理学检查 CP 中毒的大鼠组织

The present study investigated the nephron-testicular protective effects of sesamin against cisplatin (CP)-induced acute renal and testicular injuries.Thirty-two male Wistar rats were allocated to receive carboxymethylcellulose (0.5%, as sesamin vehicle), CP (a single i.p. 5 mg/kg dose), CP plus sesamin at 10 or 20 mg/kg orally for 10 days.Data analysis showed significant increases in serum urea, creatinine, interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF-α), as well as renal and testicular tissue malondialdehyde and nitric-oxide concentrations in CP-intoxicated rats in comparison to control animals. On the contrary, rats treated with CP only exhibited significantly lower (p < .05) serum testosterone, tissue glutathione, and activities of endogenous antioxidant enzymes compared to control rats. Histopathologically examining CP-intoxicated rats' tissues using H&E and PAS stains showed atrophied glomeruli, interstitial inflammatory cells, atypic tubular epithelium with focal apoptosis, and reduced mucopolysaccharide content. Further, immunohistochemical staining of the same group revealed an increase in p53 and cyclooxygenase-II (Cox-II) expression in renal and testicular tissues. Treatment with sesamin alleviated almost all the changes mentioned above in a dose-dependent manner, with the 20 mg/kg dose restoring several parameters' concentrations to normal ranges.In brief, sesamin could protect the kidneys and testes against CP toxicity through its antioxidant, anti-inflammatory, and anti-apoptotic effects.