诱导铁死亡的光敏剂缓解缺氧肿瘤微环境，以增强荧光成像引导的光动力治疗。
Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy.
发表日期：2024 Jul 16
作者：
Linhao Zhang, Maomao He, Xiang Xia, Zhiyuan Ma, Chengyuan Lv, Ran Wang, Wenkai Liu, Jiangli Fan, Xiaojun Peng, Wen Sun
来源：
Cellular & Molecular Immunology
摘要：
本研究描述了H2O2激活的光敏剂纳米颗粒（ICyHD NPs），它通过结合Zn2抑制组蛋白脱乙酰酶，诱导铁死亡并上调细胞内O2，从而增强光动力治疗效果。 ICyHD NPs 对小鼠具有很强的抗肿瘤作用，并通过观察细胞荧光的增加提高了治疗精度。
This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.