吸烟与 HPV 感染风险增加有关。然而，在服务不足和研究不足的人群中，电子烟和大麻的使用、香烟的数量以及血清可替宁浓度与 HPV（6、11、16、18）和高危 HPV（16 或 18）感染的关系仍然很差。数据包括 2013-2016 年 NHANES 中 687 名男性和 664 名女性，其中 489 名白人、375 名黑人和 342 名西班牙裔，患有 HPV 和高危 HPV 感染。吸烟史包括当前和过去的吸烟者、香烟数量、电子烟的使用、大麻和血清可替宁水平。进行了加权多变量调整逻辑回归模型。在总体人群中，高危 HPV 感染与当前吸烟史加上 ≥ 20 支/天的吸烟史相关（OR=1.92，95% CI=1.09，3.37）。在总体人群中，使用电子烟（5 天）与高危 HPV 感染呈正相关（OR=2.43，95% CI=1.13，5.22），在女性和女性中使用电子烟（过去 30 天）也有类似的发现。白人。 大量吸烟、电子烟使用和大麻与总体人群中的 HPV 和高危 HPV 感染有关。当按性别和种族/民族分层时，大多数这些关联仍然很重要。这些人群越来越多地使用电子烟和大麻，需要进一步调查以预防 HPV 感染和相关癌症。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Smoking is associated with an increased risk of HPV infection. However, the use of e-cigarettes and marijuana, number of cigarettes, and serum cotinine concentrations in relation with HPV (6, 11, 16, 18) and high-risk HPV (16 or 18) infections in underserved and understudied populations remain poorly understood.Data included 687 males and 664 females among whom 489 were White, 375 were Black and 342 were Hispanics from the NHANES 2013-2016 with HPV and high-risk HPV infections. Smoking history included current and past smokers, number of cigarettes, use of e-cigarettes, marijuana, and serum cotinine levels. Weighted multivariable-adjusted logistic regression models were conducted.High-risk HPV infection was associated with current smoking history plus ≥ 20 cigarettes/day (OR=1.92, 95 % CI=1.09, 3.37) in the overall population. E-cigarettes use (5 days) was positively associated with high-risk HPV infection (OR=2.43, 95 % CI=1.13, 5.22) in the overall population, with similar findings with e-cigarette (past 30 days) among women and Whites.High number of cigarettes, e-cigarette usage and marijuana were associated with HPV and high-risk HPV infections in the overall population. Most of these associations remained significant when stratified by gender and race/ethnicity. Increasing use of e-cigarettes and marijuana in these population warrants further investigation for the prevention of HPV infection and related cancers.Copyright © 2024 Elsevier Inc. All rights reserved.